ID A0A7K4YDP4_BUCAB Unreviewed; 326 AA.
AC A0A7K4YDP4;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE SubName: Full=HEYL protein {ECO:0000313|EMBL:NWR57146.1};
DE Flags: Fragment;
GN Name=Heyl {ECO:0000313|EMBL:NWR57146.1};
GN ORFNames=BUCABY_R13657 {ECO:0000313|EMBL:NWR57146.1};
OS Bucorvus abyssinicus (Northern ground-hornbill) (Abyssinian
OS ground-hornbill).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Bucerotiformes; Bucorvidae; Bucorvus.
OX NCBI_TaxID=153643 {ECO:0000313|EMBL:NWR57146.1, ECO:0000313|Proteomes:UP000551127};
RN [1] {ECO:0000313|EMBL:NWR57146.1, ECO:0000313|Proteomes:UP000551127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-012-80 {ECO:0000313|EMBL:NWR57146.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000256|ARBA:ARBA00038262}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWR57146.1}.
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DR EMBL; VYZL01001425; NWR57146.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K4YDP4; -.
DR OrthoDB; 6371181at2759; -.
DR Proteomes; UP000551127; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProtKB-ARBA.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR FunFam; 4.10.280.10:FF:000012; hairy/enhancer-of-split related with YRPW motif protein 1; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000551127};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 43..98
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 120..152
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWR57146.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:NWR57146.1"
SQ SEQUENCE 326 AA; 35153 MW; 8BBE34352311C7B8 CRC64;
MKRLCEESSS DTESDGTIDV GREEEYSHVS RSVSPTTTSQ IQARKKRRGI IEKRRRDRIN
SSLSELRRLV PTAFEKQGSS KLEKAEILQM TVDHLKMLHA TGGAGFLDAR ALAVDYRSIG
FRECLTEVVR YLGILEGQNA ADPIRLRLLS HLNNYVAEME PSPVATSLLP IQTWPWSFLH
SAAGPVQIPR REAAPAPVVL TASSLAYPSP AVRPAPLRRV PSDMLPSRRS FLASRMASSS
RRARGTGSSA AVAAVPRMPS PAGVLREGSS KSSQITTFLF SPASAGIPVP PAYAAPPALG
TAAQGPGIRV GTSRICRSWA TEIGAF
//
