ID A0A7K5A7T5_9AVES Unreviewed; 148 AA.
AC A0A7K5A7T5;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=Gastric inhibitory polypeptide {ECO:0000256|ARBA:ARBA00013490};
DE AltName: Full=Glucose-dependent insulinotropic polypeptide {ECO:0000256|ARBA:ARBA00031537};
DE Flags: Fragment;
GN Name=Gip {ECO:0000313|EMBL:NWR79743.1};
GN ORFNames=CENUNI_R13701 {ECO:0000313|EMBL:NWR79743.1};
OS Centropus unirufus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Otidimorphae; Cuculiformes;
OC Centropidae; Centropus.
OX NCBI_TaxID=1118519 {ECO:0000313|EMBL:NWR79743.1, ECO:0000313|Proteomes:UP000517892};
RN [1] {ECO:0000313|EMBL:NWR79743.1, ECO:0000313|Proteomes:UP000517892}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-017-25 {ECO:0000313|EMBL:NWR79743.1};
RC TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NWR79743.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC inhibitor of gastric acid secretion. {ECO:0000256|ARBA:ARBA00002766}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWR79743.1}.
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DR EMBL; VYZI01000870; NWR79743.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K5A7T5; -.
DR OrthoDB; 8874823at2759; -.
DR Proteomes; UP000517892; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031769; F:glucagon receptor binding; IEA:TreeGrafter.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR GO; GO:0042594; P:response to starvation; IEA:TreeGrafter.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR039078; GIP.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000517892};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..148
FT /note="Gastric inhibitory polypeptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029807065"
FT DOMAIN 38..66
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|Pfam:PF00123"
FT REGION 74..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWR79743.1"
FT NON_TER 148
FT /evidence="ECO:0000313|EMBL:NWR79743.1"
SQ SEQUENCE 148 AA; 16489 MW; B1CAB84E61850398 CRC64;
MSLKVVSLLL ASLGFVLMEE NIPGVSARAP AARAMHRRYS EATVASDYSR AMDTMLKKNF
VEWLLARREK KSDNIIEPTK REAEPQGPAA SGQRWERGTP EATELFSWLL KAKENQSLAS
LEGSEGLKDV LNSEFLAWLM STDLCRGT
//
