ID A0A7K5BQJ4_MOTAL Unreviewed; 2969 AA.
AC A0A7K5BQJ4;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 20.
DE RecName: Full=Neurobeachin {ECO:0000256|ARBA:ARBA00073055};
DE AltName: Full=Lysosomal-trafficking regulator 2 {ECO:0000256|ARBA:ARBA00080802};
DE Flags: Fragment;
GN Name=Nbea {ECO:0000313|EMBL:NWR98273.1};
GN ORFNames=MOTALB_R01143 {ECO:0000313|EMBL:NWR98273.1};
OS Motacilla alba (White wagtail) (Pied wagtail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passeroidea; Motacillidae; Motacilla.
OX NCBI_TaxID=45807 {ECO:0000313|EMBL:NWR98273.1, ECO:0000313|Proteomes:UP000532252};
RN [1] {ECO:0000313|EMBL:NWR98273.1, ECO:0000313|Proteomes:UP000532252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-75 {ECO:0000313|EMBL:NWR98273.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWR98273.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Interacts with RII subunit of PKA.
CC {ECO:0000256|ARBA:ARBA00065599}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the WD repeat neurobeachin family.
CC {ECO:0000256|ARBA:ARBA00008498}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWR98273.1}.
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DR EMBL; VXBE01002206; NWR98273.1; -; Genomic_DNA.
DR Proteomes; UP000532252; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:TreeGrafter.
DR GO; GO:0008104; P:protein localization; IEA:TreeGrafter.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 2.130.10.10:FF:000036; Neurobeachin isoform A; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR FunFam; 2.30.29.30:FF:000059; neurobeachin isoform X1; 1.
DR FunFam; 2.60.120.200:FF:000010; neurobeachin isoform X2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF62; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000532252};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2149..2257
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2276..2586
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1847..1857
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWR98273.1"
FT NON_TER 2969
FT /evidence="ECO:0000313|EMBL:NWR98273.1"
SQ SEQUENCE 2969 AA; 330723 MW; ADC0B87E4289C095 CRC64;
MASEKPVSGP DPQPAGLISV GAGGGGGGGG GGSSVAVMGE LRASGSGSVV LPAGMINPSV
PIRNIRMKFA VLIGLIQVGE VSNRDIVETV LNLLVGGEFD LEMNFIIQDA ESITCMSELL
EHCDVTCQAE IWSMFTAILR KSVRNLQTST EVGLIEQVLL KMSTVDDMIA DLLVDMLGVL
ASYSITVKEL KLLFSMLRGE NGIWPRHAVK LLSVLNQMPQ RHGPDTFFNF PGCSAAAIAL
PPIAKWPYQN GFTLNTWFRM DPLNNINVDK DKPYLYCFRT SKGVGYSAHF VGNCLIVTSL
KSKGKGFQHC VKYDFQPRKW YMISIVHIYN RWRNSEIRCY VNGQLVSYGD MAWHVNTNDS
YDKCFLGSSE TADANRVFCG QLGAVYVFTE ALNPAQIFAI HQLGPGYKST FKFKSESDIH
LAEHHKQVLY DGKLASSIAF TYNAKATDAQ LCLESSPKEN PSIFVHSPHA LMLQDVKAIV
THSIHSAIHS IGGIQVLFPL FAQLDNRQLH DSQVETTVCA TLLAFLVELL KSSVAMQEQM
LGGKGFLVIG YLLEKSSRVH ITRAVLEQFL SFAKYLDGLS HGAPLLKQLC DHILFNPAIW
IHTPAKVQLS LYTYLSAEFI GTATIYNTIR RVGTVLQLMH TLKYYYWVVN PADSSGITPK
GLDGPRPSQK EIISLRAFML LFLKQLILKD RGVKEDELQS ILNYLLTMHE DENIHDVLQL
LVALMSEHPA SMIPAFDQRN GIRVIYKLLA SKSESIWVQA LKVLGYFLKH LGHKRKVEIM
HTHSLFTLLG ERLMLHTNTV TVTTYNTLYE ILTEQVCTQV VHKPHPEPDS TVKIQNPMIL
KVVATLLKNS TPSAELMEVR RLFLSDMIKL FSNSRENRRC LLQCSVWQDW MFSLGYINPK
NSEEQKITEM VYNIFRILLY HAIKYEWGGW RVWVDTLSIA HSKVTYEAHK EYLAKMYEEY
QRQEEENIKK GKKGNVSTIS GLSSQTTGAK GGMEIREIED LSQSQSPESE TDYPVNTDTR
DLLMATKVSD DVLGTAERPG GGGVHVEVHD LLVDIKAEKV EATEVKLDDM DLSPETLGTG
ENGALVEVES LLDNVYSAAV EKLQNNVHGS VGIIKKNEEK DNGPLITLAD EKDEPSTNNT
SFLFDKIPSQ EEKLLPELSS NHIAIPNVQE TQMHLGVNDD LGLLAHMTGN VDITCASSII
EDKEFKIHTT SDGMNSISER ELSSSSKGLE YAEMTATTLE TESSGSKTVP NVDAGSIISD
TERSDDGKEA GKEIRKIQTT TTTQAIQGRS VTQQDRDLRV DLGFRGMPMT EEQRRQFSPG
PRTTMFRIPE FKWSPMHQRL LTDLLFALET DVHVWRSHST KSVMDFVNSN ENIIFVHNTI
HLISQMVDNI IIACGGILPL LSAATSPTGS KVSIAATELE NIEVTQGMSA ETAVTFLSRL
MAMVDVLVFA SSLNFSEIEA EKNMSSGGLM RQCLRLVCCV AVRNCLECRQ RQRERVNKTS
LIGGKTQDAL QGVTASAATK TPLENVPGNL SPIKDPDRLL QDVDINRLRA VVFRDVDDSK
QAQFLALAVV YFISVLMVSK YRDILEPQRE TARSGSQAGR NIRQEINSPT STVVVIPSIP
HPSLNHGFLA KLIPEQSFAH SFYKETPTVF PENIKDKETP TPVEDIQLES SIPHTDSGIG
DEQMPNILNG TDLETSTGPD AMSELLSTLS SEVKKSQESL TESPSEILKP ASSISSISQS
KGINVKEILK SLVAAPVEIA ECGPDPIPYP DPALKREAQA ILPMQFHSFD RSVVVPVKKP
PPGSLAVTTV GAATAGSGLP PGSTPNIFAA TGATPKSMIN TTGAVDSGSS SSSSSSSFVN
GATSKNLPAV QTVAPMPEDS AENMSITAKL ERALEKVAPL LREIFVDFAP FLSRTLLGSH
GQELLIEGLV CMKSSTSVVE LVMLLCSQEW QNSIQKNAGL AFIELINEGR LLCHAMKDHI
VRVANEAEFI LNRQRAEDVH KHAEFESQCA QYAADRREEE KMCDHLISAA KHRDHVTANQ
LKQKILNILT NKHGAWGAVS HSQLHDFWRL DYWEDDLRRR RRFVRNAFGS THADALLKAA
VEYGTEEDVV KSKKTFRSQA VVNQNAETEL MLEGDDDAVS LLQEKEIDNL AGPVVLSTPA
QLIAPVVVAK GTLSITTTEI YFEVDEDDSA FKKIDPKVLA YTEGLHGKWM FSEIRAVFSR
RYLLQNTALE VFMANRTSVM FNFPDQATVK KVVYSLPRVG VGTSYGLPQA RRISLATPRQ
LYKSSNMTQR WQRREISNFE YLMFLNTIAG RTYNDLNQYP VFPWVLTNYE SEELDLTLPG
NFRDLSKPIG ALNPKRAVFY AERYETWEDD QTPPYHYNTH YSTSTSTLAW LVRIEPFTTF
FLNANDGKFD HPDRTFSSVA RSWRNSQRDT SDVKELIPEF YYLPEMFVNS NGYNLGIRED
EIVVNDVDLP PWAKKPEDFV RINRMALESE FVSCQLHQWI DLIFGYKQRG PEAVRALNVF
HYLTYEGSVN LDSITDPVLR EIPEAYFIRD PHTFLLTKDF IKAMEAQIQN FGQTPSQLLI
EPHPPRSSAM HLCFLPQSPL MFKDQMQQDV IMVLKFPSNS PVTHVAANTL PHLTIPAVVT
VTCSRLFAVN RWHNTVGLRG APGYSLDQAH HLPIEMDPLI ANNSGVNKRQ ITDLVDQSIQ
INAHCFVVTA DNRYILICGF WDKSFRVYST ETGKLTQIVF GHWDVVTCLA RSESYIGGDC
YIVSGSRDAT LLLWYWSGRH HIIGDNPNSS DYPAPRAVLT GHDHEVVCVS VCAELGLVIS
GAKEGPCLVH TITGDLLRAL EGTENCLYPR LISVSSEGHC IIYYERGRFS NFSINGKLLA
QMEINDSTRA ILLSSDGQNL VTGGDNGVVE VWQACDFKQL YIYPGCDAGI RAMDLSHDQR
TLITGMASGS IVAFNIDFNR WHYEHQNRY
//
