ID A0A7K5IW09_TOXRE Unreviewed; 431 AA.
AC A0A7K5IW09;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=Cleavage stimulation factor subunit 1 {ECO:0000256|ARBA:ARBA00074323};
DE AltName: Full=Cleavage stimulation factor 50 kDa subunit {ECO:0000256|ARBA:ARBA00029851};
DE Flags: Fragment;
GN Name=Cstf1 {ECO:0000313|EMBL:NWS85453.1};
GN ORFNames=TOXRED_R09143 {ECO:0000313|EMBL:NWS85453.1};
OS Toxostoma redivivum (California thrasher).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Mimidae; Toxostoma.
OX NCBI_TaxID=99882 {ECO:0000313|EMBL:NWS85453.1, ECO:0000313|Proteomes:UP000523146};
RN [1] {ECO:0000313|EMBL:NWS85453.1, ECO:0000313|Proteomes:UP000523146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-15 {ECO:0000313|EMBL:NWS85453.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWS85453.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the multiple factors required for polyadenylation and
CC 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the
CC interaction of CSTF with other factors to form a stable complex on the
CC pre-mRNA. {ECO:0000256|ARBA:ARBA00058408}.
CC -!- SUBUNIT: Homodimer. The CSTF complex is composed of CSTF1 (50 kDa
CC subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts
CC (via repeats WD) directly with CSTF3. Interacts (via repeat WD6) with
CC BARD1. Interacts with ERCC6. {ECO:0000256|ARBA:ARBA00066148}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWS85453.1}.
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DR EMBL; VXBI01006779; NWS85453.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K5IW09; -.
DR Proteomes; UP000523146; Unassembled WGS sequence.
DR GO; GO:0005848; C:mRNA cleavage stimulating factor complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:TreeGrafter.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR FunFam; 1.20.960.50:FF:000001; Cleavage stimulation factor subunit 1; 1.
DR FunFam; 2.130.10.10:FF:000064; Cleavage stimulation factor subunit 1; 1.
DR FunFam; 2.130.10.10:FF:000089; Cleavage stimulation factor subunit 1; 1.
DR Gene3D; 1.20.960.50; Cleavage stimulation factor subunit 1, dimerisation domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR044633; CstF1-like.
DR InterPro; IPR032028; CSTF1_dimer.
DR InterPro; IPR038184; CSTF1_dimer_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44133; CLEAVAGE STIMULATION FACTOR SUBUNIT 1; 1.
DR PANTHER; PTHR44133:SF2; CLEAVAGE STIMULATION FACTOR SUBUNIT 1; 1.
DR Pfam; PF16699; CSTF1_dimer; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000523146};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 8..60
FT /note="Cleavage stimulation factor subunit 1 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16699"
FT REPEAT 104..138
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..210
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 258..299
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 309..343
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWS85453.1"
FT NON_TER 431
FT /evidence="ECO:0000313|EMBL:NWS85453.1"
SQ SEQUENCE 431 AA; 48346 MW; 9A045AE843789374 CRC64;
MYRTKVSLKD RQQLYKLIIS QLLYDGYINI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN
DDSAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG
QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA
FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT
LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NASANMYVTG SKDGCIKLWD GVSNRCITTF
EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVKYTGAGLS GRQVHRTQAV
FNHTEDYVLL PDERTISLCC WDSRTAERRN LLSLGHNSIV RCIVHSPTNP GFMTCSDDYR
ARFWYRRSTT D
//
