ID A0A7K5KLI3_9TYRA Unreviewed; 879 AA.
AC A0A7K5KLI3;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE Flags: Fragment;
GN Name=Znf598 {ECO:0000313|EMBL:NWT06711.1};
GN ORFNames=MIOMAC_R14791 {ECO:0000313|EMBL:NWT06711.1};
OS Mionectes macconnelli (McConnell's flycatcher).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Tyrannidae; Mionectes.
OX NCBI_TaxID=254557 {ECO:0000313|EMBL:NWT06711.1, ECO:0000313|Proteomes:UP000525714};
RN [1] {ECO:0000313|EMBL:NWT06711.1, ECO:0000313|Proteomes:UP000525714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-003-16 {ECO:0000313|EMBL:NWT06711.1};
RC TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NWT06711.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ZNF598/HEL2 family.
CC {ECO:0000256|ARBA:ARBA00035113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWT06711.1}.
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DR EMBL; VYZC01001229; NWT06711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K5KLI3; -.
DR Proteomes; UP000525714; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR CDD; cd16615; RING-HC_ZNF598; 1.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR041888; RING-HC_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:NWT06711.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000525714};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 20..60
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 281..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..346
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWT06711.1"
FT NON_TER 879
FT /evidence="ECO:0000313|EMBL:NWT06711.1"
SQ SEQUENCE 879 AA; 98002 MW; 682363B0AAB14B61 CRC64;
AEAAMAAMAG AGPGPAEGPC VLCCGELDVL ALGRCEHPIC YRCSVRMRAL CGVRYCAVCR
EELRQVVFGR KLPSFSSIAL HQLQHEKKYD IYFMDGEVYA LYRKLLQHEC SLCPDAKPFN
TFADLEQHMR KQHELFCCKL CVKHLKIFTS ERKWYSRKDL ARHRIHGDPD DTSHRGHPLC
KFCDERYLDN DELLKHLRRD HYFCHFCDSD GAQEYYSDYE YLREHFREKH FLCEEGRCST
EQFTHAFRTE IDYKAHKTAC HSKSRAEARQ NRHIDLQFTY TPRHPRRNDG VVGAEDYEEV
DRYNRQGRTG RLNGRGSQQN RRGSWRYKRE EEDRDVAAAV RASVAAKRQE EKKRVEDKED
GGSSRGKKED LRDPDTKRAP KCPNDAAGEC AAEAAANGAL SQDDFPAIGS AAGPLQGSAQ
PALVKLKEED FPSLSSSAAP TISSGMSLTY TATAKKAAFQ EEDFPALVSK MKPNNKTVAN
ITSAWNNGSS KSVVKAITNP CVSQPAKKPS LNTSKGSKKS NKLCESDDED GGGGLTTQEI
RNTPTMFDVS SLLAASTSQT FTKVGKKKKV GVEKQRPSSP RPSPDTAFPR PSMEKPLEAE
QPCKAFPAPH GPDRPTAVVN GHSEKSSAVC GTPKEPPGLK KPTVTNKCPL PQEDFPALGS
SGSARMPPPP GFNSVVLLKN PPPPPGLSVP VSKPPPGFAV IPSTNISEPV TTALKEPKSC
HGSYLIPENF QQRNIQLIQS IKEFLQSDES KFNKFKTHSG QFRQGVISAA QYYKSCRELL
GENFRKIFKE LLVLLPDTAK QQELLSAHND FRVKEKQSSN RPKKNKKNVW QVDSPADLDC
YICPTCKQVL TQQDVVTHKA LHIEDEEFPS LQAISRIIS
//
