ID A0A7K5LG26_VIRAL Unreviewed; 155 AA.
AC A0A7K5LG26;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 16.
DE RecName: Full=Iron-sulfur cluster assembly 2 homolog, mitochondrial {ECO:0000256|ARBA:ARBA00073313};
DE AltName: Full=HESB-like domain-containing protein 1 {ECO:0000256|ARBA:ARBA00077082};
DE Flags: Fragment;
GN Name=Isca2 {ECO:0000313|EMBL:NWT17425.1};
GN ORFNames=VIRALT_R07826 {ECO:0000313|EMBL:NWT17425.1};
OS Vireo altiloquus (Black-whiskered vireo) (Muscicapa altiloqua).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Corvoidea; Vireonidae; Vireoninae; Vireo.
OX NCBI_TaxID=34956 {ECO:0000313|EMBL:NWT17425.1, ECO:0000313|Proteomes:UP000589495};
RN [1] {ECO:0000313|EMBL:NWT17425.1, ECO:0000313|Proteomes:UP000589495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-22 {ECO:0000313|EMBL:NWT17425.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWT17425.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. May be
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000256|ARBA:ARBA00057540}.
CC -!- SUBUNIT: Heterotetramer; forms a dimer of dimers with IBA57. Interacts
CC with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57
CC complex; [2Fe-2S] cluster binding is absolutely required to promote the
CC complex formation. {ECO:0000256|ARBA:ARBA00093471}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family.
CC {ECO:0000256|ARBA:ARBA00006718}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWT17425.1}.
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DR EMBL; VZRF01011436; NWT17425.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K5LG26; -.
DR Proteomes; UP000589495; Unassembled WGS sequence.
DR GO; GO:0120510; C:mitochondrial [4Fe-4S] assembly complex; IEA:UniProtKB-ARBA.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:TreeGrafter.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR FunFam; 2.60.300.12:FF:000006; Iron-sulfur cluster assembly 2 mitochondrial; 1.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR InterPro; IPR016092; ATAP.
DR InterPro; IPR000361; ATAP_core_dom.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR PANTHER; PTHR43011; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43011:SF1; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000589495}.
FT DOMAIN 46..148
FT /note="Core"
FT /evidence="ECO:0000259|Pfam:PF01521"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWT17425.1"
FT NON_TER 155
FT /evidence="ECO:0000313|EMBL:NWT17425.1"
SQ SEQUENCE 155 AA; 16409 MW; 8366B90476817637 CRC64;
RGSRCPASPC PGRALPRPPA GSALRWASSV SEPGPTESGS SEGQVFLSES CVKRLLEIAE
GSEFLRLQVE GGGCSGFQYK FSLDTVINPD DRQGHKGVVM GRCGARVVVD VDSLAFVKGS
MVDFSQELIR SSFQVVSNPQ AEKGCSCGTS FSVKF
//
