ID A0A7K5TH76_9FRIN Unreviewed; 161 AA.
AC A0A7K5TH76;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 17.
DE SubName: Full=VIP protein {ECO:0000313|EMBL:NWU03065.1};
DE Flags: Fragment;
GN Name=Vip {ECO:0000313|EMBL:NWU03065.1};
GN ORFNames=UROPYL_R06958 {ECO:0000313|EMBL:NWU03065.1};
OS Urocynchramus pylzowi.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passeroidea; Fringillidae; Urocynchramus.
OX NCBI_TaxID=571890 {ECO:0000313|EMBL:NWU03065.1, ECO:0000313|Proteomes:UP000524542};
RN [1] {ECO:0000313|EMBL:NWU03065.1, ECO:0000313|Proteomes:UP000524542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-012-38 {ECO:0000313|EMBL:NWU03065.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWU03065.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: VIP is a neuropeptide involved in a diverse array of
CC physiological processes through activating the PACAP subfamily of class
CC B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor
CC 2 (VPR2). Abundantly expressed throughout the CNS and peripheral
CC nervous systems where they primarily exert neuroprotective and immune
CC modulatory roles. Also causes vasodilation, lowers arterial blood
CC pressure, stimulates myocardial contractility, increases glycogenolysis
CC and relaxes the smooth muscle of trachea, stomach and gall bladder.
CC {ECO:0000256|ARBA:ARBA00049976}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWU03065.1}.
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DR EMBL; VZRH01007407; NWU03065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K5TH76; -.
DR Proteomes; UP000524542; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0051428; F:peptide hormone receptor binding; IEA:TreeGrafter.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0048242; P:epinephrine secretion; IEA:TreeGrafter.
DR GO; GO:0032880; P:regulation of protein localization; IEA:TreeGrafter.
DR Gene3D; 6.10.250.590; -; 2.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF5; VIP PEPTIDES; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000524542};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 92..114
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWU03065.1"
FT NON_TER 161
FT /evidence="ECO:0000313|EMBL:NWU03065.1"
SQ SEQUENCE 161 AA; 18548 MW; C5153F31E382CB78 CRC64;
RLGNRMPFDG ASEPDHARGS LKSESDILQN TLPENEKFYF DLSRIIDRNA RHADGIFTSV
YSHLLAKLAV KRYLHSLIRK RVSSQDSPVK RHSDAVFTDN YSRFRKQMAV KKYLNSVLTG
KRSQEELNPS KLRDEAELLE PSFSENYDAV DELLSHLPLV R
//
