ID A0A7K6E8E0_9PASS Unreviewed; 225 AA.
AC A0A7K6E8E0;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
DE Flags: Fragment;
GN Name=Insig2 {ECO:0000313|EMBL:NWV35479.1};
GN ORFNames=GRAPIC_R13948 {ECO:0000313|EMBL:NWV35479.1};
OS Grantiella picta.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Meliphagoidea; Meliphagidae; Grantiella.
OX NCBI_TaxID=266360 {ECO:0000313|EMBL:NWV35479.1, ECO:0000313|Proteomes:UP000575029};
RN [1] {ECO:0000313|EMBL:NWV35479.1, ECO:0000313|Proteomes:UP000575029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-029-50 {ECO:0000313|EMBL:NWV35479.1};
RC TISSUE=Heart {ECO:0000313|EMBL:NWV35479.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC {ECO:0000256|RuleBase:RU241113}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU241113}.
CC -!- SIMILARITY: Belongs to the INSIG family.
CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWV35479.1}.
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DR EMBL; VZRM01003541; NWV35479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K6E8E0; -.
DR Proteomes; UP000575029; Unassembled WGS sequence.
DR GO; GO:0032937; C:SREBP-SCAP-Insig complex; IEA:TreeGrafter.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:TreeGrafter.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:TreeGrafter.
DR GO; GO:0036316; P:SREBP-SCAP complex retention in endoplasmic reticulum; IEA:TreeGrafter.
DR InterPro; IPR025929; INSIG_fam.
DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR PANTHER; PTHR15301:SF10; INSULIN-INDUCED GENE 2 PROTEIN; 1.
DR Pfam; PF07281; INSIG; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|RuleBase:RU241113};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU241113};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU241113};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW Reference proteome {ECO:0000313|Proteomes:UP000575029};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW ECO:0000256|RuleBase:RU241113};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU241113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU241113}.
FT TRANSMEM 28..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 131..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWV35479.1"
FT NON_TER 225
FT /evidence="ECO:0000313|EMBL:NWV35479.1"
SQ SEQUENCE 225 AA; 24852 MW; E4B419B2407CA1C8 CRC64;
MAENDAMPTL PKKCGPYISS VTSRGMNLVI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP
DVITSIFSSA WWVPPCCGTA SAVIGLLYPC MDRHLGEPHK FKREWSSVMR CVAVFVGINH
ASAKVDFANN IQLSLTLAAL SIGLWWTFDR SRSGFGLGVG IAFLATLVSQ LLVYNGVYQY
TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHED
//
