ID A0A7K6K280_9PASE Unreviewed; 677 AA.
AC A0A7K6K280;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE RecName: Full=WD repeat-containing protein 48 {ECO:0000256|ARBA:ARBA00021209};
DE AltName: Full=USP1-associated factor 1 {ECO:0000256|ARBA:ARBA00031683};
DE Flags: Fragment;
GN Name=Wdr48 {ECO:0000313|EMBL:NWW06660.1};
GN ORFNames=OREARF_R11117 {ECO:0000313|EMBL:NWW06660.1};
OS Oreocharis arfaki (tit berrypecker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passeroidea; Paramythiidae; Oreocharis.
OX NCBI_TaxID=979223 {ECO:0000313|EMBL:NWW06660.1, ECO:0000313|Proteomes:UP000542358};
RN [1] {ECO:0000313|EMBL:NWW06660.1, ECO:0000313|Proteomes:UP000542358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-029-42 {ECO:0000313|EMBL:NWW06660.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWW06660.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Late
CC endosome {ECO:0000256|ARBA:ARBA00004603}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR48 family.
CC {ECO:0000256|ARBA:ARBA00006917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWW06660.1}.
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DR EMBL; VZRR01006123; NWW06660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K6K280; -.
DR Proteomes; UP000542358; Unassembled WGS sequence.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043130; F:ubiquitin binding; IEA:TreeGrafter.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProtKB-ARBA.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProtKB-ARBA.
DR CDD; cd17041; Ubl_WDR48; 1.
DR CDD; cd00200; WD40; 1.
DR FunFam; 2.130.10.10:FF:000054; Putative WD repeat-containing protein 48; 1.
DR FunFam; 2.130.10.10:FF:002031; WD repeat domain 48b; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR020472; WD40_PAC1.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR051246; WDR48.
DR InterPro; IPR021772; WDR48/Bun107.
DR PANTHER; PTHR19862; WD REPEAT-CONTAINING PROTEIN 48; 1.
DR PANTHER; PTHR19862:SF14; WD REPEAT-CONTAINING PROTEIN 48; 1.
DR Pfam; PF11816; DUF3337; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000542358};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 26..60
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 71..112
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 113..154
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 164..205
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 206..247
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 607..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..620
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWW06660.1"
FT NON_TER 677
FT /evidence="ECO:0000313|EMBL:NWW06660.1"
SQ SEQUENCE 677 AA; 76243 MW; CCFFB03D39F8E317 CRC64;
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN
QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV
KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQMG
TVIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG
QQRCIATYRV HDEGVWALQV NEAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM
ELDRSADPPP ALWVATTKSS VNKWTLKGIH NFRASGDYDN DCTNPIPPLC TQPDQVIKGG
ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEEEIKKR FKMVYVPNWF
SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHIN
PMDEEENEIN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM
LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHSSSGAKTL KKDRLSASDM LQVRKVMEHV
YEKIINLDNE SQTTSSSNNE KAGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF
IWKSGGDLTL HYRQKST
//
