ID A0A7K6MI88_PANBI Unreviewed; 343 AA.
AC A0A7K6MI88;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 17.
DE RecName: Full=CCN family member 2 {ECO:0000256|ARBA:ARBA00039943};
DE AltName: Full=Cellular communication network factor 2 {ECO:0000256|ARBA:ARBA00042353};
DE AltName: Full=Connective tissue growth factor {ECO:0000256|ARBA:ARBA00041320};
DE Flags: Fragment;
GN Name=Ctgf_1 {ECO:0000313|EMBL:NWW36449.1};
GN ORFNames=PANBIA_R06005 {ECO:0000313|EMBL:NWW36449.1};
OS Panurus biarmicus (Bearded tit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Sylviidae; Sylviidae incertae sedis; Panurus.
OX NCBI_TaxID=181101 {ECO:0000313|EMBL:NWW36449.1, ECO:0000313|Proteomes:UP000545574};
RN [1] {ECO:0000313|EMBL:NWW36449.1, ECO:0000313|Proteomes:UP000545574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-030-18 {ECO:0000313|EMBL:NWW36449.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Major connective tissue mitoattractant secreted by vascular
CC endothelial cells. Promotes proliferation and differentiation of
CC chondrocytes. Mediates heparin- and divalent cation-dependent cell
CC adhesion in many cell types including fibroblasts, myofibroblasts,
CC endothelial and epithelial cells. Enhances fibroblast growth factor-
CC induced DNA synthesis. {ECO:0000256|ARBA:ARBA00046208}.
CC -!- SUBUNIT: Monomer. Interacts with TSKU. {ECO:0000256|ARBA:ARBA00046496}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWW36449.1}.
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DR EMBL; VZRT01001300; NWW36449.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K6MI88; -.
DR Proteomes; UP000545574; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 2.20.100.10:FF:000036; Connective tissue growth factor (Predicted); 1.
DR FunFam; 2.10.70.10:FF:000015; CYR61 isoform 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR050941; CCN.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF7; CCN FAMILY MEMBER 2; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000545574};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..343
FT /note="CCN family member 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029772030"
FT DOMAIN 19..92
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 95..161
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 250..324
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWW36449.1"
FT NON_TER 343
FT /evidence="ECO:0000313|EMBL:NWW36449.1"
SQ SEQUENCE 343 AA; 37406 MW; 870CC6400296A7BA CRC64;
TFAPFAVALL LALLSPEAQG QECSGQCQCG AGPGPTCPAG VSLVLDGCGC CRVCAKQLGE
LCTERDPCDH HKGLFCDFGS PANRRIGVCT ARDGAPCVFS GMVYRSGESF QSSCKYQCTC
LDGAVGCVPL CSMDVRLPSP DCPYPRRVKL PGKCCEEWVC DEAKEQTAVG PALAAYRLED
TYGPDPTMMR ANCLVQTTEW SACSKTCGMG ISTRVTNDNA FCRLEKQSRL CMVRPCEADL
EENIKKGKKC IRTPKISKPV KFELSGCTSV KTYRAKFCGV CTDGRCCTPH RTATLPVEFK
CPDGEIMKKK MMFIKTCACH YNCPGDNDIF ESLYYRKMYG DMA
//
