ID A0A7K7E0V0_9SYLV Unreviewed; 538 AA.
AC A0A7K7E0V0;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE SubName: Full=SOCS5 protein {ECO:0000313|EMBL:NWY38929.1};
DE Flags: Fragment;
GN Name=Socs5 {ECO:0000313|EMBL:NWY38929.1};
GN ORFNames=SYLATR_R12448 {ECO:0000313|EMBL:NWY38929.1};
OS Sylvia atricapilla (blackcap).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Sylviidae; Sylviinae; Sylvia.
OX NCBI_TaxID=48155 {ECO:0000313|EMBL:NWY38929.1, ECO:0000313|Proteomes:UP000573818};
RN [1] {ECO:0000313|EMBL:NWY38929.1, ECO:0000313|Proteomes:UP000573818}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0013 {ECO:0000313|EMBL:NWY38929.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWY38929.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWY38929.1}.
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DR EMBL; VZSL01000023; NWY38929.1; -; Genomic_DNA.
DR RefSeq; XP_066172156.1; XM_066316059.1.
DR AlphaFoldDB; A0A7K7E0V0; -.
DR GeneID; 136359434; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000573818; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000573818};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 383..478
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 473..522
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 118..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWY38929.1"
FT NON_TER 538
FT /evidence="ECO:0000313|EMBL:NWY38929.1"
SQ SEQUENCE 538 AA; 61667 MW; 8CFE56A60C3CBB51 CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSQNETI VVNPNNCSSG KDKAIQITDL TQQQQQPSSP
LRENIALQLG LSPSKNSVRR NQNCVTEIPQ IVEISIEKEN DSCVTTGARL ARRDSYSRHA
PWGGKKKHSC STKTQSSLDT EKRFGRTRSG LQRRERRYGV SSVHDMDAVS SRTVGSRSLR
QRLQDTVGLC FPMRTYSKQS KPLFSNKRKI HLSELMLEKC PFPAGSDLAQ KWHLIKQHTA
PVSPHSTFFD TFDPSLVSTE DEEDRLRERR RLSIEEGVDP PPNAQIHTFE ATAQVNPLYK
LGPKLAPGMT ELTGDKTITP PGNCDSEEDT TTLCLQSRRQ KQRQMSGESH GHISRQGAWK
VHTQIDYIHC LVPDLLQITG NPCYWGVMDR YEAEALLEGK PEGTFLLRDS AQEDYLFSVS
FRRYNRSLHA RIEQWNHNFS FDAHDPCVFH SSTVTGLLEH YKDPSSCMFF EPLLTVSLNR
TFPFSLQYIC RAVICRCTTY DGIDDLPLPS MLQDFLKEYH YKQKVRVRWL EREPIKTK
//
