ID A0A7K7EV34_9SYLV Unreviewed; 989 AA.
AC A0A7K7EV34;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE SubName: Full=TRPC5 protein {ECO:0000313|EMBL:NWY48818.1};
DE Flags: Fragment;
GN Name=Trpc5 {ECO:0000313|EMBL:NWY48818.1};
GN ORFNames=SYLATR_R02354 {ECO:0000313|EMBL:NWY48818.1};
OS Sylvia atricapilla (blackcap).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Sylviidae; Sylviinae; Sylvia.
OX NCBI_TaxID=48155 {ECO:0000313|EMBL:NWY48818.1, ECO:0000313|Proteomes:UP000573818};
RN [1] {ECO:0000313|EMBL:NWY48818.1, ECO:0000313|Proteomes:UP000573818}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0013 {ECO:0000313|EMBL:NWY48818.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWY48818.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWY48818.1}.
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DR EMBL; VZSL01000117; NWY48818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K7EV34; -.
DR Proteomes; UP000573818; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR FunFam; 1.25.40.20:FF:000023; short transient receptor potential channel 4 isoform X1; 1.
DR FunFam; 1.10.287.70:FF:000266; Transient receptor potential cation channel subfamily c member 1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005461; TRPC5_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF76; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01646; TRPCHANNEL5.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000573818};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 327..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..238
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 767..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 227..254
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 770..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWY48818.1"
FT NON_TER 989
FT /evidence="ECO:0000313|EMBL:NWY48818.1"
SQ SEQUENCE 989 AA; 113677 MW; 1A665B7A2C8AE209 CRC64;
MAQLYYKKVN FSPYRDRIPL QIVRAEAELS SEEKAYLSAV EKGDYASVKH ALQEAEIYYN
ININCMDPLG RSALLIAIEN ENLEIMELLL SHSVYVGDAL LYAIRKEVVG AVELLLNYRK
PSGEKQVPTL MMDTQFSEFT PDITPIMLAA HTNNYEIIKL LVQRRVTIPR PHQIRCNCVE
CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE
YEELSQQCKR FAKDLLDQAR SSRELEIILN HRDDQSEELD PQKCHDLAKL KVAIKYHQKE
FVAQPNCQQL LATLWYDGFP GWRRKHWAVK LLTCVTIGML FPVLSVAYLI APKSRLGLFI
KKPFIKFICH TGSYLTFLFM LLLASQHIVR TDLHMQGPPP TIVEWMILPW VLGFIWGEIK
EMWDGGFNEY VHDWWNLMDF AMNSLYLATI SLKIVAYVKY NGSRPREEWE MWHPTLIAEA
LFAISNILSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
YYETSASEEP NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGATLPPP
FNIVPSPKSV WYLCKWIHNQ LCPGDDSDNE QKRHENLKTF TERHADNLIQ NQHYQEVIRN
LVKRYVAAMI RTSKTNEGLT EENFKELKQD ISSFRYEVLD LLGNRKPQRR SYSTSSTEVS
QKDETNEDGA GEKPRAKSVS FNVANKKKDF NVSALIKTMS GINMVEEKPK SNGISKRSFV
RNGNRVQRLS SSKKESFKRL GLLFSKMNGH VPEPSSEPMY TISDGIIQPH YMWKDIKYSP
MDREREENCS KSEINLNEVA YSGNTRLTGQ SKECPVVCTS SLHCASSICS SNSKLIDSSE
DVFDSWGEAC DLFINQWKDG QEDHVTTRL
//
