ID A0A7K7G743_ERIRU Unreviewed; 3813 AA.
AC A0A7K7G743;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 13.
DE SubName: Full=LYST regulator {ECO:0000313|EMBL:NWY65390.1};
DE Flags: Fragment;
GN Name=Lyst {ECO:0000313|EMBL:NWY65390.1};
GN ORFNames=ERIRUB_R00053 {ECO:0000313|EMBL:NWY65390.1};
OS Erithacus rubecula (European robin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Turdidae; Erithacus.
OX NCBI_TaxID=37610 {ECO:0000313|EMBL:NWY65390.1, ECO:0000313|Proteomes:UP000529965};
RN [1] {ECO:0000313|EMBL:NWY65390.1, ECO:0000313|Proteomes:UP000529965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0015 {ECO:0000313|EMBL:NWY65390.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWY65390.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWY65390.1}.
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DR EMBL; VZSK01000255; NWY65390.1; -; Genomic_DNA.
DR Proteomes; UP000529965; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 2.130.10.10:FF:000292; Lysosomal trafficking regulator; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF86; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000529965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3021..3127
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3132..3434
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3624..3658
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 134..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2098..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2212..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1026
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1231
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWY65390.1"
FT NON_TER 3813
FT /evidence="ECO:0000313|EMBL:NWY65390.1"
SQ SEQUENCE 3813 AA; 427788 MW; 60ED0F5D065FD56F CRC64;
MSSASNSLAR EFLTDVNRLC NAVVQRTEAK EDEEEETHMA ALGQYLVQGR GFILLTTLNS
IIDQELTCRE ELLTLLLSLL PLVWKIPVQE EKAIDFNIPF TVDICLTKEN NQSSMKSTQE
KLSLDGSVHS SLQTPVKLSL RSRRSGRLRK TTHRYSVRDA RRSQLSTSDS EGNSDEKTAV
ITKHRRSQIL QPFLSPSVRD SYPGGRSDCR PPKVVPGSKT DTSNLESSSK FVPAHEILNE
PAAGTSESNM DNSPFDLCHV LLSLLEKVCK FDITLNHSST LSASVVPTLT EFLSGFGDSC
NVSSNTENEV VSAGWTEEPV ALIQRMLFRT VLHLMSLDIS NTETMPDNLR RNLTDLLKAA
LKIRICLEKQ PGPFASGYKK TLQQLVQDDY IFSRYRHRAL LLPEVIEGVL QILICCLQSA
ASNPFYFSQA IDLVHEFIQQ QGFKLFEVTV LQMEWLCMKN EGVPGEASEH LKALINSIMK
IISTVKKVKS DQLHQSMCTR KRHRRCEYSH FMNHHRDLSG LSVSAFKNQA SKSPFETADG
EVDYPERCCC IAVCAHQCLH LLQQVSLSST CSEILSGVYN VGICCCMDPK SVIVPLLHAS
KLPILKNFQQ HILNILNKFI LDQLGGAEVS PKIIQASCNI CTVDSDQLAQ LEDALQGNSS
DTSPTSSSSC RVQGILPSTG SEDMLLRWHA LEAYQDIIFE EDKLRGAQIA SHICHLIQKG
NVVVQWKLYN CIYHPVLQRG VELACHAQQQ LGLSTADKLL CSYHSQDLPS EVLQVYLQML
PMLLKSRVIR DLFLSCNGVN QMIELNYLDT LRSHSLKVLE TLILCLDDQQ EDQATPELEG
LNSEQKESMS DLPTSLCSQP AISEVPQSLS KFYAGLKEAY PKKKKFVSQD IHVNTINLFL
CVAFLCISKE ADGDLDSANE CEDTSGYDST ASEPLGHKLP YLSLESLTLP PLEHIHRAAD
IWSMCRCIYL YSSVFQRQFH RLGGFEACRR LIILIIQKLA KNKEKEQEKR GRVLSESSRS
SHGSPRTELL NKDDSVQLAK SREVMQLELD SSGSPASAEQ LVPDSVSCDS PLSMEHTLVS
SVASVEGIKT SARGETEWAL QGIRLLEALL TICLHSASTI QQKTEGEMFH QNTCVDDILL
EIREQLAQSK VIETDLAKPL FDSLLRVALG TFSADLDHSE EKIEKTHYPE KEPVSQPGEI
SEETEESQCC SLKLFAEEEG YEADSESNPD DSETKNEGAD TKAEPGCTGV SGYFNGLAEN
INQGELMYPE ICMLELNLLS AGNASLDVLA HVFQSCLNII SQKERNATVL IEQGAVKHLL
GGFLNILTQT DSSFHACQVV LVDLLVSLMS SQTCSEELTL LLRIFLEKTP CTEVLLKGVL
KIVNTNIYMN PLQYLAFPFL NGTNLSSSSS QKCTGTSNNK NAGLLKRAKL SHSKKEADGE
NLSHQLLSSW HVAPIHLPLV GQNCWPHMSD GFSVSLWFRL EYTHETEGST EKGKKVKWRN
RLIPVRENSF DSTEETKTIG MEYASLGDKL VEDGCIHIIS LGSKALMIQV WADLNTGAFI
FRMCMDPNDE MKAGLLAQAE SPGNVFLVGR WQHLALTYLQ KPEGKKNFHG KLLLWVSGQR
QCEINLDFAL PRKTSLSSDS NKTFCMIGHC TSSQEDLLRL SGRWDLGNLL LFNGANIGPE
EAFYLYSCGP DFTSVMPCKY GKTLIDCSKY ISKEILQCEQ VKELFMAKKE VDIGILIESL
AVVYATSCPG QYTIYEPVIR LKGQVKTVPS QRPFSLKEVQ SNVLDPYHLK ALQPVEYKTL
QAILHEIGGT GAFVFLFARV VEISSCEDTQ ALALQLILSL TKYNQQRIQE MDNCNGYSMI
RRVLIKPQCI VGFCMLKTLL EGCCSDEILY INESGQFQLD PDSTAVIQDV QLLEKLLLDW
KIWSKAKQGV WETLLAALEI LIRANHHQQM FNIKQLLKAQ VVHHFLLTCQ VLQEHKEGHL
ASLPREVCRS FVKIIEEVLG SPPDLELLTL VFNFLLAVHP PTNTYVCHNP TNFYFSLHID
GKIFQEKVES LRYLRNSSSG GKSVDNSAFV ITSPTGFTAL PLEGSTSKTS VQQKITSQVP
RRLSKSLPAS PTSSPQVHQK RLGSSVDDLQ ILSERDYVDL QGRIGLVESS ETAKRVQEEL
FLSSCESAKT VCDSELTSAE TFEDIAKEVE LSENALESKE IDTELKCNEA AAGGGAAEAS
PRRPDNLKGL PSLQKGQSNF AGLGLAFSVL GASSAIARWP SLADRNVLPE DWDSLAFSSA
NENTPKPSES PDDRCAEDYL VLICCGLYDL LRGVLLILPD IMLEDVMDKL IQPDYLIVLV
NHPSPLIQQG VIKLLDAYFN RARREQKEKF LKNRGFSLLA NQLYLHQGTQ EVIECFLEML
FGRSVGLDEE FDLEDVKNVG LFRKWCVIPV LGLIENSLYD NVLLHNCFCL LLQIINSCSK
VADLLLDNGL LYVLCNTLAA LNGLETNIPL NDYKLLACDI QQLLVAVAIH ACSSSGSQYF
RVIEDLIVLL GHLQNSKNAR MQNMAVVLQL RVLQAAVELI RTTASQDAQE QASSAPAPSA
PHRAMFQKRK GIAGSRKFSL AQSDALLVKM RSLASEEFNM MMQRRMSQEN PIQATESEFA
QRLQRLTVLA VNRLIYLAST EECLDVLGIT ENASQSRLSA SQLEVPEEES QQELTSRINP
FLKEMVKMLM EGIKVSIGTS RMSTPKQQWN RILLLCKDTF RTQLGRLLVH SLSPVRPLQE
RKQALEMVQE VNQQEILRDC LSPTLQHGPK LVLYLYELMH NHSDGMTKEQ QRAAGDLMNT
LKSCGYKCIP LSPRPKPDLI KALKEDQKKY EMEQGVNKAA WEKTMANNRQ NLFQRLDTKS
KDISKIAGDI TQAVSLSQGM ERKKVIQHIR GMYKAELSAS RHWQELVQQL THDRALWYDP
VYYPTSWQLD PTEGPNRERR RLQRCYLTIP NKYLLPDRQK QEGMIKTPLS YLFEDKTHSS
HSSTVKDKAA SEHIRQSISI STLEYFRVNR RCVSVAPSRE TAGELLLGKC GMYFVEDNAS
DTIENSSFHG ETEPASFSWT YEEIKEVHKR WWQLRDNAVE IFLTNGRTLL LAFDNTKVRD
DVYHNILTNN LPNLLEYGNI TALTHLWCTG QITNFEYLTH LNKHAGRSFN DLMQYPVFPF
ILSDYTNETL DLNDPSVYRN LVKPIAVQSK EKEDRYVDTY KYLEEEYRKG AREDDPMPPV
QPYHYGSHYS NSGTVLHFLV RLPPFTKMFL AYQDQSFDIP DRTFHSTNTT WRLSSYESMT
DVKELIPEFF YLPDFLVNRE GFDFGVRQNG DRVNHVNLPP WARNDPRLFI LIHRQALESD
HVSQTICHWI DLVFGYKQKG KASVQAINVF HPATYFGMDV SAVEDPVQRR ALETMIKTYG
QTPRQLFHAA HISRPGSRLI MEGELPAAMG LLVQFAFRET REHTKEIIYP SPLPWIKGLK
WGEYVGSPSA PDPVVCFSQP HGERFGSLQA LPTKAICGLS SKFCLLMIYS KEQGVRSMHS
TDIQWSAILS WGYADNILRL KSKQSEPPVN FIQSSQLHQV TSCAWVPDSC QLFTGSKSGV
ITAYMNRFTS NTPSEIEMES QVHLYGHTAE ITSLFVCKPY SIMISVSKDG TCIIWDLNRL
CYVQSLAGHK SPVTAVSASE TTGDIATVCD SVGGGSDLRL WTVNGDLVGH VHCRESICSV
AFSNQPEGVS VNVIAGGLEN GVVRLWSTWD LKPVREITFS KSAKPIVSLT FSCDGHHLFT
ANSDGNVIAW CRKDQQRLKL PMFYSFLSSY AAG
//
