ID A0A7K7GAU3_ERIRU Unreviewed; 444 AA.
AC A0A7K7GAU3;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=Ethanolamine kinase {ECO:0000256|ARBA:ARBA00081737};
DE EC=2.7.1.32 {ECO:0000256|ARBA:ARBA00066350};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
DE Flags: Fragment;
GN Name=Chka {ECO:0000313|EMBL:NWY66752.1};
GN ORFNames=ERIRUB_R09523 {ECO:0000313|EMBL:NWY66752.1};
OS Erithacus rubecula (European robin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Turdidae; Erithacus.
OX NCBI_TaxID=37610 {ECO:0000313|EMBL:NWY66752.1, ECO:0000313|Proteomes:UP000529965};
RN [1] {ECO:0000313|EMBL:NWY66752.1, ECO:0000313|Proteomes:UP000529965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0015 {ECO:0000313|EMBL:NWY66752.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWY66752.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=choline + ATP = phosphocholine + ADP + H(+);
CC Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216;
CC EC=2.7.1.32; Evidence={ECO:0000256|ARBA:ARBA00052454};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12838;
CC Evidence={ECO:0000256|ARBA:ARBA00052454};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ethanolamine + ATP = phosphoethanolamine + ADP + H(+);
CC Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC EC=2.7.1.82; Evidence={ECO:0000256|ARBA:ARBA00050770};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13070;
CC Evidence={ECO:0000256|ARBA:ARBA00050770};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWY66752.1}.
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DR EMBL; VZSK01000502; NWY66752.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K7GAU3; -.
DR Proteomes; UP000529965; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004103; F:choline kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004305; F:ethanolamine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:TreeGrafter.
DR CDD; cd05156; ChoK_euk; 1.
DR FunFam; 3.90.1200.10:FF:000005; Choline kinase alpha; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603:SF36; CHOLINE KINASE ALPHA; 1.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:NWY66752.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000529965};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..27
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWY66752.1"
FT NON_TER 444
FT /evidence="ECO:0000313|EMBL:NWY66752.1"
SQ SEQUENCE 444 AA; 50589 MW; AC0281A8C6B9E34E CRC64;
MKTKFCNGDA DPSPLGLLLG RGSAAAGQPP SPLAHPEPEG KDPTAAGRGG GVATPPPALP
PPLEEESPPL DPRTRRRAYL WCKEFLPGAW RGLREEQLCI SPIRGGLSNM LFQCSLPDTI
ETVADEPRKV LLRLYGAILQ MRSCNKGESV QSQKENDLQG AEAMVLESVM FAILAERALG
PKLYGIFPQG RLEEFIPSRK LNTEELSLPD ISAEIAEKMA RFHGMKMPFN KEPKWLFGTM
EKYLNQVLRI KFTRESQTRK LNKLLSYNLP QEMKNLRAML EATSSPVVFC HNDCQEGNIL
LLEGRENSEN QKLMLIDFEY SSYNYRGFDI GNHFCEWMYD YSYEKYPFFK ASALKYPSKK
QQLHFLSSYL SAFHDGFENL SNEEKSKLEE EVLVEVNRFA LASHFFWGLW SIIQAKISSI
EFGYLEYALS RFDAYFDQKR KLKV
//
