ID A0A7K7YXX1_THRLU Unreviewed; 1044 AA.
AC A0A7K7YXX1;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 {ECO:0000256|ARBA:ARBA00040288};
DE EC=7.2.2.10 {ECO:0000256|ARBA:ARBA00012790};
DE AltName: Full=Calcium pump 2 {ECO:0000256|ARBA:ARBA00042814};
DE AltName: Full=Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform {ECO:0000256|ARBA:ARBA00042557};
DE AltName: Full=Endoplasmic reticulum class 1/2 Ca(2+) ATPase {ECO:0000256|ARBA:ARBA00041515};
DE Flags: Fragment;
GN Name=Atp2a2 {ECO:0000313|EMBL:NXA82846.1};
GN ORFNames=THRLUD_R11755 {ECO:0000313|EMBL:NXA82846.1};
OS Thryothorus ludovicianus (Carolina wren) (Sylvia ludoviciana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Certhiidae; Troglodytinae; Thryothorus.
OX NCBI_TaxID=74200 {ECO:0000313|EMBL:NXA82846.1, ECO:0000313|Proteomes:UP000558509};
RN [1] {ECO:0000313|EMBL:NXA82846.1, ECO:0000313|Proteomes:UP000558509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-68 {ECO:0000313|EMBL:NXA82846.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXA82846.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIA subfamily. {ECO:0000256|ARBA:ARBA00005675}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXA82846.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VZTB01015658; NXA82846.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K7YXX1; -.
DR Proteomes; UP000558509; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR CDD; cd02083; P-type_ATPase_SERCA; 1.
DR FunFam; 2.70.150.10:FF:000143; Calcium-transporting ATPase; 1.
DR FunFam; 3.40.1110.10:FF:000003; Calcium-transporting ATPase; 1.
DR FunFam; 3.40.50.1000:FF:000005; Calcium-transporting ATPase 1; 1.
DR FunFam; 1.20.1110.10:FF:000065; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; 3.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 3.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR005782; P-type_ATPase_IIA.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01116; ATPase-IIA1_Ca; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF08282; Hydrolase_3; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000558509};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 834..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1015..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..78
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXA82846.1"
FT NON_TER 1044
FT /evidence="ECO:0000313|EMBL:NXA82846.1"
SQ SEQUENCE 1044 AA; 115052 MW; 667C1BF5902ACEAA CRC64;
AMENAHTKTV EEVLAYFGVN ESTGLSLEQV KKLKEKWGSN ELPAEEGKTL LELVIEQFED
LLVRILLLAA CISFVLAWFE EGEETITAFV EPFVILLILV ANAIVGVWQE RNAENAIEAL
KEYEPEMGKV YRQDRKSVQR IKARDIVPGD IVEVAVGDKV PADIRITSIK STTLRVDQSI
LTGESVSVIK HTDPVPDPRA VNQDKKNMLF SGTNIAAGKA MGVVIATGVN TEIGKIRDEM
VATEQERTPL QQKLDEFGEQ LSKVISLICI AVWIINIGHF NDPVHGGSWI RGAIYYFKIA
VALAVAAIPE GLPAVITTCL ALGTRRMAKK NAIVRSLPSV ETLGCTSPLL PLLPLLPLLP
LLPLLPMFIL DRVEGDSCSL NEFTVTGSTY APMGEVHKDD KLIKCSQYDG LVELATICAL
CNDSSLDYNE AKGVYEKVGE ATETALTCLV EKMNVFDTDL KGLSRIERAN ACNSVIKQLM
KKEFTLEFSR DRKSMSVYCT PNKPSRTSMS KMFVKGAPEG VIDRCTHVRV GNAKIPLTSG
IKQKIMSVIR EWGTGRDTLR CLALATHDNP PKKEEMNLED SSNFINYETN LTFVGCVGML
DPPRIEVASS IKLCRQAGIR VIMITGDNKG TAVAICRRIG IFVEDEDVST KAFTGREFDE
LSLAAQRDAC HHARCFARVE PSHKSKIVEF LQSFDEITAM TGDGVNDAPA LKKAEIGIAM
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA
LGFPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMNKP PRNPKEPLIS GWLFFRYLAI
GCYVGAATVG AAAWWFIAAD GGPKVSFYQL SHFLQCKEDN PDFYGVDCVV FESPYPMTMA
LSVLVTIEMC NALNSLSENQ SLMRMPPWEN IWLVGAICLS MSLHFLILYV EPLPIIFQIT
PLNVTQWLMV LKISLPVILL DETLKYVARN YLEPGKDDSV RPATKPCALS ACTEGVSWPF
VFITLPLVIW LYSTDTNFSD MFWS
//
