ID A0A7K8JUF9_9AVES Unreviewed; 433 AA.
AC A0A7K8JUF9;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=Ethanolamine kinase {ECO:0000256|ARBA:ARBA00081737};
DE EC=2.7.1.32 {ECO:0000256|ARBA:ARBA00066350};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
DE Flags: Fragment;
GN Name=Chka {ECO:0000313|EMBL:NXE06525.1};
GN ORFNames=LOPRUF_R02071 {ECO:0000313|EMBL:NXE06525.1};
OS Lophotis ruficrista.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Otidimorphae; Otidiformes;
OC Otididae; Lophotis.
OX NCBI_TaxID=172689 {ECO:0000313|EMBL:NXE06525.1, ECO:0000313|Proteomes:UP000533896};
RN [1] {ECO:0000313|EMBL:NXE06525.1, ECO:0000313|Proteomes:UP000533896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-CU-031-23 {ECO:0000313|EMBL:NXE06525.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=choline + ATP = phosphocholine + ADP + H(+);
CC Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216;
CC EC=2.7.1.32; Evidence={ECO:0000256|ARBA:ARBA00052454};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12838;
CC Evidence={ECO:0000256|ARBA:ARBA00052454};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ethanolamine + ATP = phosphoethanolamine + ADP + H(+);
CC Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC EC=2.7.1.82; Evidence={ECO:0000256|ARBA:ARBA00050770};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13070;
CC Evidence={ECO:0000256|ARBA:ARBA00050770};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXE06525.1}.
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DR EMBL; VWYV01000133; NXE06525.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K8JUF9; -.
DR OrthoDB; 3649325at2759; -.
DR Proteomes; UP000533896; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004103; F:choline kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004305; F:ethanolamine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:TreeGrafter.
DR CDD; cd05156; ChoK_euk; 1.
DR FunFam; 3.90.1200.10:FF:000005; Choline kinase alpha; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603:SF36; CHOLINE KINASE ALPHA; 1.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:NXE06525.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000533896};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 28..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXE06525.1"
FT NON_TER 433
FT /evidence="ECO:0000313|EMBL:NXE06525.1"
SQ SEQUENCE 433 AA; 49001 MW; 8F41661B041CA761 CRC64;
MKTKFCNGET DPSPLGLLLS CSSSGGGVVL PAAGQPPSPL AHADPEGKDP VAAGKGGGAG
TPPSALLLPP PPPEEEPPLD PRTRRKAYLW CKEGGLSNML FQCSLPDTIE TVADEPRKVL
LRLYGAILQM RSCNKGESVQ SQKENDLQGA EAMVLESVMF AILAERALGP RLYGIFPQGR
LEEFIPSRKL STEELSLPDI SAEIAEKMAR FHGMKMPFNK EPKWLFGTME KYLNQVLRIK
FTGESKTRKL NKLLSYNLPQ EMKNLRAMLE ATSSPVVFCH NDCQEGNVLL LEGRENSENQ
KLMLIDFEYS SYNYRGFDIG NHFCEWMYDY TYEKYPFFKA SVLKYPSKKQ QLHFISSYLT
AFHDGFENLN NEERSKLEEE VFIEVNRFAL ASHFFWGLWS IIQAKISSIE FGYLEYALSR
FDAYFDQKKK LKV
//
