ID A0A7K9D1V3_9AVES Unreviewed; 1045 AA.
AC A0A7K9D1V3;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE SubName: Full=CRIM1 protein {ECO:0000313|EMBL:NXG58734.1};
DE Flags: Fragment;
GN Name=Crim1 {ECO:0000313|EMBL:NXG58734.1};
GN ORFNames=HEMCOM_R04747 {ECO:0000313|EMBL:NXG58734.1};
OS Hemiprocne comata.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Strisores; Apodiformes; Apodidae;
OC Hemiprocninae; Hemiprocne.
OX NCBI_TaxID=243314 {ECO:0000313|EMBL:NXG58734.1, ECO:0000313|Proteomes:UP000518305};
RN [1] {ECO:0000313|EMBL:NXG58734.1, ECO:0000313|Proteomes:UP000518305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-23 {ECO:0000313|EMBL:NXG58734.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXG58734.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXG58734.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VWZJ01005042; NXG58734.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K9D1V3; -.
DR OrthoDB; 5976811at2759; -.
DR Proteomes; UP000518305; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 6.20.200.20; -; 6.
DR Gene3D; 2.10.22.10; Antistasin, domain 1; 4.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR052624; CRIM1.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00093; VWC; 4.
DR Pfam; PF23334; VWC2L_2nd; 2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 3.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 3.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000518305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..1045
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029539978"
FT TRANSMEM 950..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..118
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 343..400
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 410..466
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 478..507
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 514..541
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 548..573
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 576..601
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 615..672
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 686..744
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 760..818
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 826..883
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXG58734.1"
FT NON_TER 1045
FT /evidence="ECO:0000313|EMBL:NXG58734.1"
SQ SEQUENCE 1045 AA; 114930 MW; 642F56ACBAA85C86 CRC64;
MYLAAVSAGR RRPAGDGGWH LAATGWLFLL ALLLGESGTR ALVCLPCDES KCEEPKSCPG
SIVLGICRCC FMCARQRNES CGGVYGLHGA CDLGLRCVIR PPLNGDSITE YEQVCLFILD
ENWDDDQLLG FEPCNENLIT GCNIINGKCE CDTIRTCNNP FEFPSRDTCL SALKRIEEEK
PDCSKARCEV QFSPRCPEDS ILIEGYAPPG ECCPLPSRCV CNPAGCLRKV CQPGYLNILV
SKASGKPGEC CDLYECKPVF SVDCSTVECP PVQQVVCPLD SYETQVRLTA DGCCTLPTRC
ECLSGLCGFP MCEAGSIPQI VSRGDGTPGK CCDVFECVNE VKPTCIFNSM EYHDGDIFRM
DACRFCRCQG GVSICFSAQC GELHCDGYYV PEGECCPVCE DPVYPVNNPA GCYANGQIQA
HGDRWREDDC TFCQCINGDP HCVATACGQS CLNPVKVPGE CCPVCEEPTY ITIGPPTCEI
LVNCTLTEKD CIYSFKLDQN GCRICQCKTR EELCTGLISG CSLDCSFGFQ TDVHNCEICQ
CRPRPKKCKP IVCDKYCPFG YLKNKHGCES CRCKKCPDLP CGKICPMGFQ QNKHGCIICK
CREATASLMP PVKTGSCLSM DGRRHENEES WHDGCRECYC HNGREMCALI TCPVPNCGNP
TIYPGQCCPS CPDEIIVQKP ELTSPSICHA PGGEYFVEGE TWNIDSCTQC TCHSGRVLCE
TEVCPPLLCQ NPTRTQDSCC PQCPDEPLQP SSSSNESMPS YCKNDEGDIF LTAESWKPNV
CTSCVCMDGV IRCYSESCPP VSCERPVLRK GQCCPYCIED TVPKKVVCHF NGKTYADEER
WDIDSCTHCY CLQGQTLCST VSCPPLPCAE PINVEGSCCP MCPEMYVPEP TNIPIEKTNH
RADVELAVPN WPTPSENDII HIHRDMNHLQ GEYRSGGGPH PSEDASVSSI ALVTIPITIA
LLLIIVLLLI NQKKQWIPVS CYKAPTKPSC LNNQLVYVDC KKGTMVQVDS SQRMLRIADP
DSRYSGFYSM QKQNNLQADN FYQTV
//
