ID A0A7K9EWC6_BARMA Unreviewed; 145 AA.
AC A0A7K9EWC6;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 12.
DE RecName: Full=Gastric inhibitory polypeptide {ECO:0000256|ARBA:ARBA00013490};
DE AltName: Full=Glucose-dependent insulinotropic polypeptide {ECO:0000256|ARBA:ARBA00031537};
DE Flags: Fragment;
GN Name=Gip {ECO:0000313|EMBL:NXG81012.1};
GN ORFNames=BARMAR_R09505 {ECO:0000313|EMBL:NXG81012.1};
OS Baryphthengus martii (Rufous motmot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Coraciiformes; Momotidae; Baryphthengus.
OX NCBI_TaxID=176943 {ECO:0000313|EMBL:NXG81012.1, ECO:0000313|Proteomes:UP000578343};
RN [1] {ECO:0000313|EMBL:NXG81012.1, ECO:0000313|Proteomes:UP000578343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-21 {ECO:0000313|EMBL:NXG81012.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXG81012.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC inhibitor of gastric acid secretion. {ECO:0000256|ARBA:ARBA00002766}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXG81012.1}.
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DR EMBL; VWZK01022241; NXG81012.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K9EWC6; -.
DR OrthoDB; 8874823at2759; -.
DR Proteomes; UP000578343; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031769; F:glucagon receptor binding; IEA:TreeGrafter.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR GO; GO:0042594; P:response to starvation; IEA:TreeGrafter.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR039078; GIP.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000578343};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..145
FT /note="Gastric inhibitory polypeptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029880119"
FT DOMAIN 39..65
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|SMART:SM00070"
FT REGION 71..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXG81012.1"
FT NON_TER 145
FT /evidence="ECO:0000313|EMBL:NXG81012.1"
SQ SEQUENCE 145 AA; 16364 MW; 711B537670F4EAF3 CRC64;
MSFKVLPLLL ASLGFVLMEE NVSGVSIRAP GARAVQRRYS EATLASDYSR TMDNMLKKNF
VEWLLTRREK KSEEPYKREA EPQVPAASGR TLDLGSQEAK DFVDWLLKAK KNQSSTPLEG
SEGLKDVLNQ ELLMWLLSTD LCRPT
//
