ID A0A7K9F4J6_STEPR Unreviewed; 607 AA.
AC A0A7K9F4J6;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
DE Flags: Fragment;
GN Name=Glce {ECO:0000313|EMBL:NXG84076.1};
GN ORFNames=STEPAR_R06957 {ECO:0000313|EMBL:NXG84076.1};
OS Stercorarius parasiticus (Parasitic jaeger) (Arctic skua).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Stercorariidae;
OC Stercorarius.
OX NCBI_TaxID=54059 {ECO:0000313|EMBL:NXG84076.1, ECO:0000313|Proteomes:UP000532908};
RN [1] {ECO:0000313|EMBL:NXG84076.1, ECO:0000313|Proteomes:UP000532908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-20 {ECO:0000313|EMBL:NXG84076.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXG84076.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00037847}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXG84076.1}.
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DR EMBL; VWZL01001293; NXG84076.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K9F4J6; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000532908; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR InterPro; IPR059154; Glce_b_sandwich.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR Pfam; PF21174; Glce_b_sandwich; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000532908};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 258..378
FT /note="D-glucuronyl C5-epimerase beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF21174"
FT DOMAIN 406..597
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
FT REGION 40..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..78
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXG84076.1"
FT NON_TER 607
FT /evidence="ECO:0000313|EMBL:NXG84076.1"
SQ SEQUENCE 607 AA; 68476 MW; A438C029EAC59594 CRC64;
MRCLAARVNY KTLIVICALF TLVMVLLWNR CSSDRAGPFP RSLAGPERRG AAAAASESDP
ARQQSEEASP QEQQKAPPIA GGFNGNKAPG LKYEEIDCLI NDEHTVKGRR EGNEVFLPFS
WVEKYFEVYG KIAQYDGYDR FEFSHSYSKV YTQRAPYHPD GVFMSFEGYN VEVRDRVKCI
SGVEGVPLST QWGPQGYFYP IQIAQYGLSH YSKNLTEKPP HIEVYETAEE KDKTGRSVDW
TVPKGCSLST VSDKAKFTSV KQFVAPENTE GVSLQLGNTR DFIISFDLKF VTNGSISVVL
ETTEKNQLFT VHYVSNTQLI AFKDRDIYYG IGPRTSWSTL TRDLVTDLRK GVGLSNTKAV
KQTKIMPKRV VRLVAKGRGF LDNITISATA HMAAFFAASN WLLRNQDERG GWPIMVTRKL
GEGFKSLDPG WYSAMAQGQA ISTLVRAYLL TKDHAFLSSA LRATAPYKLP SEQRGVKAVF
MNRHDWYEEY PTSPSSFVLN GFMYSLIGLY DLKETAGEKL GKEARVLYER GMESLKAMLP
LYDTGSGTIY DLRHFMLGTA PNLARWDYHT THINQLQLLS TIDESPIFKE FVKRWKSYLR
GGRAKHN
//
