ID A0A7K9Q2T1_9CORV Unreviewed; 405 AA.
AC A0A7K9Q2T1;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 16.
DE SubName: Full=SOCS4 protein {ECO:0000313|EMBL:NXI05763.1};
DE Flags: Fragment;
GN Name=Socs4 {ECO:0000313|EMBL:NXI05763.1};
GN ORFNames=PACPHI_R13703 {ECO:0000313|EMBL:NXI05763.1};
OS Pachycephala philippinensis (yellow-belllied whistler).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Corvoidea; Pachycephalidae; Pachycephala.
OX NCBI_TaxID=449367 {ECO:0000313|EMBL:NXI05763.1, ECO:0000313|Proteomes:UP000570547};
RN [1] {ECO:0000313|EMBL:NXI05763.1, ECO:0000313|Proteomes:UP000570547}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-28 {ECO:0000313|EMBL:NXI05763.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXI05763.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXI05763.1}.
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DR EMBL; VWZT01015934; NXI05763.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K9Q2T1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000570547; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000570547};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 251..346
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 341..390
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..170
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXI05763.1"
FT NON_TER 405
FT /evidence="ECO:0000313|EMBL:NXI05763.1"
SQ SEQUENCE 405 AA; 46403 MW; CD2B8203B8E22536 CRC64;
WSGKKLSWSK KSEHCPDAET ASAAGRSGTN LRSQERKYSC SSIELDLDRS CGHRFLGRSL
KQKLQDAVGQ CFPIKNCSSR HASGLPSKRK IHISELMLDK CPFPPRSELA FRWHLIKRHT
APISPKAEEW IIADLSQHEE REDQLRDEEI ANGGMDSPSQ SCDFTDSSSS RGDPRPELVT
GKVARSSRDE SDMDSDDEVI TLCTSSRKRN KPKWETDDEL LRMETPPKYH TQIDYVHCLV
PDLLQINNNP CYWGVMDKYA AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR RYSRSLHARI
EQWNHNFSFD AHDPCVFHSP DITGLLEHYK DPSSCMFFEP LLSTPLNRTF PFSLQHICRT
VICNCTTYDG IDALPIPPSV KLYLKEYHYK SKVRVLRIDV PEQQS
//
