ID A0A7K9Y4Q4_9GALL Unreviewed; 448 AA.
AC A0A7K9Y4Q4;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE RecName: Full=Transmembrane protease serine 5 {ECO:0000256|ARBA:ARBA00071705};
DE AltName: Full=Spinesin {ECO:0000256|ARBA:ARBA00075021};
DE Flags: Fragment;
GN Name=Tmprss5 {ECO:0000313|EMBL:NXJ04618.1};
GN ORFNames=ODOGUJ_R11045 {ECO:0000313|EMBL:NXJ04618.1};
OS Odontophorus gujanensis (marbled wood quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Odontophorus.
OX NCBI_TaxID=886794 {ECO:0000313|EMBL:NXJ04618.1, ECO:0000313|Proteomes:UP000522663};
RN [1] {ECO:0000313|EMBL:NXJ04618.1, ECO:0000313|Proteomes:UP000522663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-53 {ECO:0000313|EMBL:NXJ04618.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXJ04618.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in hearing. {ECO:0000256|ARBA:ARBA00056576}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXJ04618.1}.
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DR EMBL; VXAB01001531; NXJ04618.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K9Y4Q4; -.
DR OrthoDB; 5979691at2759; -.
DR Proteomes; UP000522663; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR FunFam; 2.40.10.10:FF:000092; Transmembrane protease serine 5; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF17; SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000522663};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|RuleBase:RU363034};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 77..172
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 210..444
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 49..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..199
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXJ04618.1"
FT NON_TER 448
FT /evidence="ECO:0000313|EMBL:NXJ04618.1"
SQ SEQUENCE 448 AA; 48043 MW; 89952FE6229D1EA2 CRC64;
SSNASPKTLC TTWRLLLLLL LGGSGLLAAA VAGAWLLGQH LGGSQPQQVL AKPQALDPGT
ACSEGEEEEP VVRGAPGRVS FRIQAGPSLL AVRPWELSQW LLACHERWQP TLGTRLCRHL
GALRAIHQKG VNLTDVEVED GQRFAQVGSS LEDAWQVRSS CESGRVVALQ CSGGSLSLHY
LSPAASSPSH PLSPGSAAAC GQRPAPGGRV VGGTDAAPGR WPWQVSVRLG SRHRCGGSVL
APRWIVTAAH CVHSYRRRSA WGWMIHAGIT HGSAKQEDGV PVERVISHPL YNDSSLDYDI
ALMKLQVPLN FSDAISALCL LPSHQDLLPG TPCWVSGWGY TRPDQAQLTE TLKEALVPLI
STQRCNSSCM YAGELTARML CAGYPQGKVD ACQGDSGGPL VCRDELAWRL VGIVSWGRGC
AEPNRPGVYT NVAQLLPWIY RVTEVRCS
//
