ID A0A7K9YMN1_9GALL Unreviewed; 229 AA.
AC A0A7K9YMN1;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE RecName: Full=CCN family member 2 {ECO:0000256|ARBA:ARBA00039943};
DE AltName: Full=Cellular communication network factor 2 {ECO:0000256|ARBA:ARBA00042353};
DE AltName: Full=Connective tissue growth factor {ECO:0000256|ARBA:ARBA00041320};
DE Flags: Fragment;
GN Name=Ctgf_2 {ECO:0000313|EMBL:NXJ10547.1};
GN ORFNames=ODOGUJ_R12367 {ECO:0000313|EMBL:NXJ10547.1};
OS Odontophorus gujanensis (marbled wood quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Odontophorus.
OX NCBI_TaxID=886794 {ECO:0000313|EMBL:NXJ10547.1, ECO:0000313|Proteomes:UP000522663};
RN [1] {ECO:0000313|EMBL:NXJ10547.1, ECO:0000313|Proteomes:UP000522663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-53 {ECO:0000313|EMBL:NXJ10547.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXJ10547.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Major connective tissue mitoattractant secreted by vascular
CC endothelial cells. Promotes proliferation and differentiation of
CC chondrocytes. Mediates heparin- and divalent cation-dependent cell
CC adhesion in many cell types including fibroblasts, myofibroblasts,
CC endothelial and epithelial cells. Enhances fibroblast growth factor-
CC induced DNA synthesis. {ECO:0000256|ARBA:ARBA00046208}.
CC -!- SUBUNIT: Monomer. Interacts with TSKU. {ECO:0000256|ARBA:ARBA00046496}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXJ10547.1}.
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DR EMBL; VXAB01007616; NXJ10547.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7K9YMN1; -.
DR OrthoDB; 365605at2759; -.
DR Proteomes; UP000522663; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0008201; F:heparin binding; IEA:TreeGrafter.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:TreeGrafter.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 2.20.100.10:FF:000036; Connective tissue growth factor (Predicted); 1.
DR FunFam; 2.10.70.10:FF:000015; CYR61 isoform 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR050941; CCN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF7; CCN FAMILY MEMBER 2; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000522663};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 3..76
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 79..145
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXJ10547.1"
FT NON_TER 229
FT /evidence="ECO:0000313|EMBL:NXJ10547.1"
SQ SEQUENCE 229 AA; 24804 MW; 34177CD5058C17C3 CRC64;
EVRGQECSAQ CQCGTEPGPS CPAGVSLVLD GCGCCRVCAK QLGELCTERD PCDHHKGLFC
DFGSPANRRI GVCTARDGAP CVFSGMVYRS GESFQSSCKY QCTCLDGAVG CVPLCSMDVR
LPSPDCPYPR RVKLPGKCCE EWVCDEAKEQ TAVGPALAAY RLEDTYGPDP TMMRANCLVQ
TTEWSACSKT CGMGISTRVT NDNAFCRLEK QSRLCMVRPC EADLEENIK
//
