ID A0A7L0B1R2_9AVES Unreviewed; 1187 AA.
AC A0A7L0B1R2;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE SubName: Full=HCN4 protein {ECO:0000313|EMBL:NXJ40988.1};
DE Flags: Fragment;
GN Name=Hcn4_0 {ECO:0000313|EMBL:NXJ40988.1};
GN ORFNames=CICMAG_R07776 {ECO:0000313|EMBL:NXJ40988.1};
OS Ciconia maguari.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Ciconiiformes;
OC Ciconiidae; Ciconia.
OX NCBI_TaxID=52777 {ECO:0000313|EMBL:NXJ40988.1, ECO:0000313|Proteomes:UP000537039};
RN [1] {ECO:0000313|EMBL:NXJ40988.1, ECO:0000313|Proteomes:UP000537039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-47 {ECO:0000313|EMBL:NXJ40988.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXJ40988.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034430};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00036239};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXJ40988.1}.
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DR EMBL; VXAE01014128; NXJ40988.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L0B1R2; -.
DR Proteomes; UP000537039; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter.
DR GO; GO:0098855; C:HCN channel complex; IEA:TreeGrafter.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0003254; P:regulation of membrane depolarization; IEA:TreeGrafter.
DR CDD; cd00038; CAP_ED; 1.
DR FunFam; 1.10.287.70:FF:000031; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative; 1.
DR FunFam; 1.10.287.630:FF:000002; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; 1.
DR FunFam; 2.60.120.10:FF:000007; Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR051413; K/Na_HCN_channel.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000537039};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 236..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..683
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..890
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..921
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..940
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..967
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1051
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1115
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXJ40988.1"
FT NON_TER 1187
FT /evidence="ECO:0000313|EMBL:NXJ40988.1"
SQ SEQUENCE 1187 AA; 129413 MW; 4570F5212C58F20D CRC64;
MDKLPPSMRK RLYSLPQQIG PKASIMDEEE DSDKDTRRKS IRLKPLPSPS AGSTRALGGD
PGRGGDPGFL ETEAGSKGAK TSTNGDCRRF KGSLSSLTSR HLHDAAEEKR LIGGEGEPAS
PSEDKSLPGS GELEQGLPAP PPPASPPEPQ QQPPRACSST SIKVEGGGGC DQITPDEEQR
LGQAGFMQRQ FGAMLQPGVN KFSLRMFGSQ KAVEREQERV KSAGFWIIHP YSDFRFYWDL
TMLLLMVGNL IIIPVGITFF KDENTTPWIV FNVVSDTFFL IDLVLNFRTG IVVEDNTEII
LDPQRIKMKY LKSWFVVDFI SSIPVDYIFL IVETRIDSEV YKTARALRIV RFTKILSLLR
LLRLSRLIRY IHQWEEIFHM TYDLASAVVR IVNLIGMMLL LCHWDGCLQF LVPMLQDFPD
DCWVSLNRMV NDSWGKQYSY ALFKAMSHML CIGYGQQAPM GMSDVWLTML SMIVGATCYA
MFIGHATALI QSLDSSRRQY QEKYKQVEQY MSFHKLPADM RQRIHDYYEH RYQGKMFDEE
SILGELSEPL REEIINFNCR KLVASMPLFA NADPNFVTSM LTKLRFEVFQ PGDYIIREGT
IGKKMYFIQH GVVSVLTKGN KETKLADGSY FGEICLLTRG RRTASVRADT YCRLYSLSVD
NFNEVLEEYP MMRRAFETVA LDRLDRIGKK NSILLHKVQH DLNSGVFNYQ ENEIIQQIVQ
HDREMAHCAH NVQAAAAAAA AAASTPTPVI WTPLIQAPLQ AAAATTSVAI ALTHHPRLPT
AIFRPPVSVL GSLGQQSNQT PRQLKRLQSL IPSTGPSAVG SPSSTPSQLH TPGAETPSSS
SFHIQQLAGF SAAASLGQFQ VGSPPGGSSQ LAQPMQQQQQ QQQQPALPSS GFGHFQQATT
SSPSTSLTQL SSNSPPSLLN QFQPTTRPLQ GGQLQQLSGS GTLGGMNHFQ PPPSSNSPSS
SLSQLAQGSG GPSSGLCQTH PSALGSLTGT IAQLHQERPP FASMSPLQQA GIASPCYTPS
GLSPPSQSPV ATRTFHCGPS GASGSHGSLL LPQTASPPPQ ILQSKSTPPV PLGRLSQDIK
LISASQPSLP QDLAQTLSQS SPHSSRESVS SFSPFPGGGT GLLGKPCSSI PGRVTLPRQM
SSGSLPHPLV FGASAAGATS LTAGGRKESI VLTGDLEPVR SKLPSNL
//
