ID   A0A7L0G5B4_HERCA        Unreviewed;       433 AA.
AC   A0A7L0G5B4;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   18-JUN-2025, entry version 16.
DE   SubName: Full=IKKA kinase {ECO:0000313|EMBL:NXK02232.1};
DE   Flags: Fragment;
GN   Name=Chuk {ECO:0000313|EMBL:NXK02232.1};
GN   ORFNames=HERCAC_R13460 {ECO:0000313|EMBL:NXK02232.1};
OS   Herpetotheres cachinnans (Laughing falcon) (Falco cachinnans).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC   Falconiformes; Falconidae; Herpetotheres.
OX   NCBI_TaxID=56343 {ECO:0000313|EMBL:NXK02232.1, ECO:0000313|Proteomes:UP000555649};
RN   [1] {ECO:0000313|EMBL:NXK02232.1, ECO:0000313|Proteomes:UP000555649}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B10K-DU-005-78 {ECO:0000313|EMBL:NXK02232.1};
RC   TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NXK02232.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:NXK02232.1}.
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DR   EMBL; VXAJ01000010; NXK02232.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A7L0G5B4; -.
DR   Proteomes; UP000555649; Unassembled WGS sequence.
DR   GO; GO:0008385; C:IkappaB kinase complex; IEA:TreeGrafter.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:TreeGrafter.
DR   CDD; cd17046; Ubl_IKKA_like; 1.
DR   FunFam; 1.20.1270.250:FF:000001; Inhibitor of nuclear factor kappa-B kinase subunit alpha; 1.
DR   FunFam; 3.10.20.90:FF:000061; Inhibitor of nuclear factor kappa-B kinase subunit alpha; 1.
DR   Gene3D; 1.20.1270.250; -; 1.
DR   Gene3D; 3.10.20.90; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1; 1.
DR   InterPro; IPR041185; IKBKB_SDD.
DR   InterPro; IPR046375; IKBKB_SDD_sf.
DR   InterPro; IPR051180; IKK.
DR   InterPro; IPR022007; IKKbetaNEMObind.
DR   PANTHER; PTHR22969; IKB KINASE; 1.
DR   PANTHER; PTHR22969:SF13; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; 1.
DR   Pfam; PF18397; IKBKB_SDD; 1.
DR   Pfam; PF12179; IKKbetaNEMObind; 1.
DR   SMART; SM01239; IKKbetaNEMObind; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:NXK02232.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000555649};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          401..431
FT                   /note="I-kappa-kinase-beta NEMO binding"
FT                   /evidence="ECO:0000259|SMART:SM01239"
FT   REGION          372..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:NXK02232.1"
FT   NON_TER         433
FT                   /evidence="ECO:0000313|EMBL:NXK02232.1"
SQ   SEQUENCE   433 AA;  49346 MW;  A84097A33D08CBE3 CRC64;
     VFFLQIVHIL NMTSAKIVSF LLYPEESLHS LQIRIEFETG ISTGNQELLL ETGICLDPRK
     PASQCVIDGV RGWDSYMVYL FDKSKTVYDG PFASRSLSDC VNYIVQDSKI QLPIPQLRKV
     WAEAVHYVIG LKEDYSRLFQ GQRAAMLSLL RYNANLIKMK NNMVSASQQL KAKLEFFHQS
     IRLDLERYSD QMAYGISSEK MLKAWKEMEE KASQCAQAED IGYLDEQIMA LHTEIVELQK
     SPYARRQGEV MESLEQRAID LYKQLKTRPP DHAYSDSTDM VKIIVQTVQS QDRVLKELFG
     HLSKLLGCKQ KIIDLLPKIE EALNNIKEAD NSVMQMQGKR QREIWHLLKI ACTQSSSRSL
     VSSSLEGTTS TSAATWLPQS SSGNIPHPLS SMATPEDGED FVHVIEENLN YLELFSSILQ
     EVRQEQNNSM MVS
//