ID A0A7L0GX38_HERCA Unreviewed; 471 AA.
AC A0A7L0GX38;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE SubName: Full=ERRFI inhibitor {ECO:0000313|EMBL:NXK12591.1};
DE Flags: Fragment;
GN Name=Errfi1 {ECO:0000313|EMBL:NXK12591.1};
GN ORFNames=HERCAC_R10333 {ECO:0000313|EMBL:NXK12591.1};
OS Herpetotheres cachinnans (Laughing falcon) (Falco cachinnans).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Falconiformes; Falconidae; Herpetotheres.
OX NCBI_TaxID=56343 {ECO:0000313|EMBL:NXK12591.1, ECO:0000313|Proteomes:UP000555649};
RN [1] {ECO:0000313|EMBL:NXK12591.1, ECO:0000313|Proteomes:UP000555649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-005-78 {ECO:0000313|EMBL:NXK12591.1};
RC TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NXK12591.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00029433}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXK12591.1}.
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DR EMBL; VXAJ01000643; NXK12591.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L0GX38; -.
DR Proteomes; UP000555649; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:TreeGrafter.
DR InterPro; IPR015116; Cdc42-bd-like.
DR InterPro; IPR052112; EGFR_SigReg_Kinase.
DR InterPro; IPR021619; Mig-6.
DR PANTHER; PTHR14254:SF5; ERBB RECEPTOR FEEDBACK INHIBITOR 1; 1.
DR PANTHER; PTHR14254; GENE 33 POLYPEPTIDE; 1.
DR Pfam; PF09027; GTPase_binding; 1.
DR Pfam; PF11555; Inhibitor_Mig-6; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000555649}.
FT DOMAIN 7..64
FT /note="Cdc42 binding"
FT /evidence="ECO:0000259|Pfam:PF09027"
FT DOMAIN 324..347
FT /note="Mig-6"
FT /evidence="ECO:0000259|Pfam:PF11555"
FT REGION 88..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXK12591.1"
FT NON_TER 471
FT /evidence="ECO:0000313|EMBL:NXK12591.1"
SQ SEQUENCE 471 AA; 51565 MW; C3FE76FDAA3805C3 CRC64;
MSTAGVAAQE MGVPLKAGFL HTGQGMGSLK TCWGSHSGFE NTFFNVDPIA VAYNLNPSTE
QRLPSIDFLT FLGHSANDAS VNAHSFAESC TQVPSQKSSP PPVSPKNEQL ISRHEDHLIP
GFSKLSLTKG CVSEETPPHM PIKNGPIQLL SASSNDRSSR PLPPLPISED LIPDEVDKEV
EFLTSSDTDF LLEDYELPPF KSSAPSRRSF RGCGQINYAY FDTPTGPKPE DASPTQSLNG
YVSSICPPPQ QLHRRLRRSH SGPAGSLNKP VVRLSGHLNR SSPNSDEDKP EIPPRVPIPP
RALKPDYRRW SAEVASSAYS DEDRPPKVPP REPLSRSNSR TPSPKSLPSY LNGVMPPTQS
FAPDPKYVSS KALQRQNSEG SSSRVPCILP IIENGKKASS THYYLLPERP PYLDKYEKFF
REAEESSSSA EVQSWSGDCT ATSAPAKLDS KPRMDIAGHL KRKHLSYVVS P
//
