ID A0A7L0WQY6_ALELA Unreviewed; 434 AA.
AC A0A7L0WQY6;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 15.
DE SubName: Full=SOCS4 protein {ECO:0000313|EMBL:NXL94081.1};
DE Flags: Fragment;
GN Name=Socs4 {ECO:0000313|EMBL:NXL94081.1};
GN ORFNames=ALELAT_R05595 {ECO:0000313|EMBL:NXL94081.1};
OS Alectura lathami (Australian brush turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Megapodiidae;
OC Alectura.
OX NCBI_TaxID=81907 {ECO:0000313|EMBL:NXL94081.1, ECO:0000313|Proteomes:UP000562322};
RN [1] {ECO:0000313|EMBL:NXL94081.1, ECO:0000313|Proteomes:UP000562322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-39 {ECO:0000313|EMBL:NXL94081.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXL94081.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXL94081.1}.
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DR EMBL; VXAV01010368; NXL94081.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L0WQY6; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000562322; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000562322};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 280..375
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 370..419
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXL94081.1"
FT NON_TER 434
FT /evidence="ECO:0000313|EMBL:NXL94081.1"
SQ SEQUENCE 434 AA; 49546 MW; 6EDC38F6013E9948 CRC64;
MAENKDSNVK NADVRPKSSR SRSADRKDGY VWSGKKLSWS KKSEHCSDAE AASAVGRAGS
NLRSQERKYS CSSIELDLDR SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHASGLQSKR
KIHISELMLD KCPFPPRSEL AFRWHLIKRH TAPISQKAED WIIADLTQNE EKEDQLRDNE
TADGGSPSLS CDLSDGVSSR RDSRSEPVTG KVVRSSKDES DMDSDDEVIT LCTSSRKRNK
PKWETDDELL RMETPPKYHT QIDYVHCLVP DLLQINNNPC YWGVMDKYAA EALLEGKPEG
TFLLRDSAQE DYLFSVSFRR YSRSLHARIE QWNHNFSFDA HDPCVFHSPD ITGLLEHYKD
PSSCMFFEPL LSTPLNRTFP FSLQHICRTV ICNCTTYDGI DALPIPPSVK LYLKEYHYKS
KVRVLRIDVP EQQS
//
