ID A0A7L1JVW5_RYNNI Unreviewed; 535 AA.
AC A0A7L1JVW5;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 15.
DE SubName: Full=SOCS5 protein {ECO:0000313|EMBL:NXN53419.1};
DE Flags: Fragment;
GN Name=Socs5 {ECO:0000313|EMBL:NXN53419.1};
GN ORFNames=RYNNIG_R08745 {ECO:0000313|EMBL:NXN53419.1};
OS Rynchops niger (Black skimmer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Laridae;
OC Rynchops.
OX NCBI_TaxID=227184 {ECO:0000313|EMBL:NXN53419.1, ECO:0000313|Proteomes:UP000525416};
RN [1] {ECO:0000313|EMBL:NXN53419.1, ECO:0000313|Proteomes:UP000525416}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-16 {ECO:0000313|EMBL:NXN53419.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXN53419.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXN53419.1}.
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DR EMBL; VXBH01003584; NXN53419.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L1JVW5; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000525416; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000525416};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 380..475
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 470..519
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 115..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXN53419.1"
FT NON_TER 535
FT /evidence="ECO:0000313|EMBL:NXN53419.1"
SQ SEQUENCE 535 AA; 61164 MW; 5C8B607190900E53 CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSQSENV AVNSSSSSAK EKAVQITDLA QQQPSSPLRE
NIALQLGLSP SKNSGRRNQN CVTEIPQIVE ISIEKENDSC VTTGARLARR DSYSRHAPWG
GKKKHSCSTK TQSSLDTEKR FGRTRSGLQR RERRYGVSSV HDMDAVSNRT VGSRSLRQRL
QETVGLCFPM RTYSKQSKPL FSNKRKIHLS ELMLEKCPFP AGSDLAQKWH LIKQHTAPVS
PHSTFFDTFD PSLVSTEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA QVNPLYKLGP
KLAPGMTELT GDKNMTSPGS CDSEEDTTTL CLQSRRQKQR QMSGESHGHI SRQGAWKVHT
QIDYIHCLVP DLLQITGNPC YWGVMDRYEA EALLEGKPEG TFLLRDSAQE DYLFSVSFRR
YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD PSSCMFFEPL LTVSLNRTFP
FSLQYICRAV ICRCTTYDGI DDLPLPSMLQ DFLKEYHYKQ KVRVRWLERE PIKTK
//
