ID A0A7L1KRZ2_HIMHI Unreviewed; 209 AA.
AC A0A7L1KRZ2;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 17.
DE RecName: Full=Gamma-secretase subunit APH-1 {ECO:0000256|RuleBase:RU369072};
DE Short=APH-1 {ECO:0000256|RuleBase:RU369072};
DE Flags: Fragment;
GN Name=Aph1a_0 {ECO:0000313|EMBL:NXN65310.1};
GN ORFNames=HIMHIM_R10200 {ECO:0000313|EMBL:NXN65310.1};
OS Himantopus himantopus (Black-winged stilt) (Charadrius himantopus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes;
OC Recurvirostridae; Himantopus.
OX NCBI_TaxID=225398 {ECO:0000313|EMBL:NXN65310.1, ECO:0000313|Proteomes:UP000571567};
RN [1] {ECO:0000313|EMBL:NXN65310.1, ECO:0000313|Proteomes:UP000571567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-13 {ECO:0000313|EMBL:NXN65310.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXN65310.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential subunit of the gamma-secretase complex, an
CC endoprotease complex that catalyzes the intramembrane cleavage of
CC integral proteins such as Notch receptors.
CC {ECO:0000256|RuleBase:RU369072}.
CC -!- SUBUNIT: Component of the gamma-secretase complex.
CC {ECO:0000256|RuleBase:RU369072}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
CC -!- SIMILARITY: Belongs to the APH-1 family.
CC {ECO:0000256|ARBA:ARBA00005577, ECO:0000256|RuleBase:RU369072}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXN65310.1}.
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DR EMBL; VXBK01002455; NXN65310.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L1KRZ2; -.
DR OrthoDB; 6507463at2759; -.
DR Proteomes; UP000571567; Unassembled WGS sequence.
DR GO; GO:0070765; C:gamma-secretase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0016485; P:protein processing; IEA:UniProtKB-UniRule.
DR InterPro; IPR009294; Aph-1.
DR PANTHER; PTHR12889; GAMMA-SECRETASE SUBUNIT APH-1; 1.
DR Pfam; PF06105; Aph-1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369072};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976,
KW ECO:0000256|RuleBase:RU369072};
KW Reference proteome {ECO:0000313|Proteomes:UP000571567};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369072};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369072}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..209
FT /note="Gamma-secretase subunit APH-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029817260"
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 79..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 117..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 149..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369072"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXN65310.1"
FT NON_TER 209
FT /evidence="ECO:0000313|EMBL:NXN65310.1"
SQ SEQUENCE 209 AA; 23168 MW; 63CD7215575ED705 CRC64;
AFFWLVSLLL SSLIWFVAVK ASDPRDEALQ KGLLIFGVMF SVLLQEAFRF LYYKLLRKAI
EGLVALSEDG CSPISIQQMA YVAGVGFGLM SGAFSMINLL ADALGPGTVG IHGDSQLYFL
TSAFMTMVLI FLHTFWGILF FHGCEHRRWW EIVAVVVMHL AVSGSTFFNP LYVGSLVPSY
LLMAIAATWA YLLSGGSVQN LRRFLLCES
//
