ID A0A7L1LK51_HIMHI Unreviewed; 220 AA.
AC A0A7L1LK51;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE RecName: Full=Protein lifeguard 2 {ECO:0000256|ARBA:ARBA00040576};
DE AltName: Full=Fas apoptotic inhibitory molecule 2 {ECO:0000256|ARBA:ARBA00042941};
DE Flags: Fragment;
GN Name=Faim2 {ECO:0000313|EMBL:NXN75398.1};
GN ORFNames=HIMHIM_R02106 {ECO:0000313|EMBL:NXN75398.1};
OS Himantopus himantopus (Black-winged stilt) (Charadrius himantopus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes;
OC Recurvirostridae; Himantopus.
OX NCBI_TaxID=225398 {ECO:0000313|EMBL:NXN75398.1, ECO:0000313|Proteomes:UP000571567};
RN [1] {ECO:0000313|EMBL:NXN75398.1, ECO:0000313|Proteomes:UP000571567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-13 {ECO:0000313|EMBL:NXN75398.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXN75398.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Interacts with FAS/TNFRSF6 and BAX.
CC {ECO:0000256|ARBA:ARBA00038784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC raft {ECO:0000256|ARBA:ARBA00004285}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034100}.
CC -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily.
CC {ECO:0000256|ARBA:ARBA00038174}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004379}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXN75398.1}.
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DR EMBL; VXBK01010926; NXN75398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L1LK51; -.
DR OrthoDB; 7933078at2759; -.
DR Proteomes; UP000571567; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:TreeGrafter.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR PANTHER; PTHR23291:SF18; PROTEIN LIFEGUARD 2; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Reference proteome {ECO:0000313|Proteomes:UP000571567};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004379};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004379}.
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 181..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..13
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXN75398.1"
FT NON_TER 220
FT /evidence="ECO:0000313|EMBL:NXN75398.1"
SQ SEQUENCE 220 AA; 24540 MW; 91D89F35B69EDB0A CRC64;
QLSVNNKPPN SEGQGEKKDN ATAPPAPPTY EEATAGEGMK AGAYPPPPSV PLHPSWAYVD
PSTSPSYGSG GYPGDTEMLT TFSWDDRNVR RVFIRKVYAI LMVQLLVTVV IVAFFTFCEP
VKGYIQTHSA WYWASYAVFF VTYLILACCS GPRRQRHALL PIVFYLKQEE NPSNYYNTKS
VLLCLGITAL VCLSVTIFSF QTKFDFTSYQ GVLFVMLMVL
//
