ID A0A7L1SH07_ARAGA Unreviewed; 436 AA.
AC A0A7L1SH07;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 16.
DE SubName: Full=SOCS4 protein {ECO:0000313|EMBL:NXO48653.1};
DE Flags: Fragment;
GN Name=Socs4 {ECO:0000313|EMBL:NXO48653.1};
GN ORFNames=ARAGUA_R01014 {ECO:0000313|EMBL:NXO48653.1};
OS Aramus guarauna (Limpkin) (Scolopax guarauna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Gruiformes; Aramidae; Aramus.
OX NCBI_TaxID=54356 {ECO:0000313|EMBL:NXO48653.1, ECO:0000313|Proteomes:UP000567570};
RN [1] {ECO:0000313|EMBL:NXO48653.1, ECO:0000313|Proteomes:UP000567570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-11 {ECO:0000313|EMBL:NXO48653.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXO48653.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXO48653.1}.
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DR EMBL; VXBL01001276; NXO48653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L1SH07; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000567570; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000567570};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 282..377
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 372..421
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..201
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXO48653.1"
FT NON_TER 436
FT /evidence="ECO:0000313|EMBL:NXO48653.1"
SQ SEQUENCE 436 AA; 49761 MW; 6689AC96F0784B0F CRC64;
MAENKDSNIK NADVRPKSSR SRSADRKDGY VWSGKKLSWS RKSEHCSDAE TASAAGRSGT
SLKNQERKYS CSSIELDLDR SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHASGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHLIKRH TAPVSPKAED WIIADLAQHE EREDQLRDDE
IANGGTDSPS QSCDFTDSSS SRGDLRSELV TGKVVRSSKD ESDMDSDDEV ITLCTSSRKR
NKPKWETDDE LLRMETPPKY HTQIDYVHCL VPDLLQINNN PCYWGVMDKY AAEALLEGKP
EGTFLLRDSA QEDYLFSVSF RRYSRSLHAR IEQWNHNFSF DAHDPCVFHS PDITGLLEHY
KDPSSCMFFE PLLSTPLNRT FPFSLQHICR TVICNCTTYD GIDALPVPPS VKLYLKEYHY
KSKVRVLRID VPEQQS
//
