ID A0A7L1SP09_ARAGA Unreviewed; 623 AA.
AC A0A7L1SP09;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
DE Flags: Fragment;
GN Name=Rnf19b {ECO:0000313|EMBL:NXO50409.1};
GN ORFNames=ARAGUA_R06022 {ECO:0000313|EMBL:NXO50409.1};
OS Aramus guarauna (Limpkin) (Scolopax guarauna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Gruiformes; Aramidae; Aramus.
OX NCBI_TaxID=54356 {ECO:0000313|EMBL:NXO50409.1, ECO:0000313|Proteomes:UP000567570};
RN [1] {ECO:0000313|EMBL:NXO50409.1, ECO:0000313|Proteomes:UP000567570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-11 {ECO:0000313|EMBL:NXO50409.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXO50409.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RBR family. RNF19 subfamily.
CC {ECO:0000256|ARBA:ARBA00061087}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXO50409.1}.
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DR EMBL; VXBL01002492; NXO50409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L1SP09; -.
DR Proteomes; UP000567570; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 2.20.25.20:FF:000004; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000052; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:NXO50409.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000567570};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 232..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..222
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 3..51
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 485..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..520
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..572
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXO50409.1"
FT NON_TER 623
FT /evidence="ECO:0000313|EMBL:NXO50409.1"
SQ SEQUENCE 623 AA; 67545 MW; AA15F91CAC21A118 CRC64;
LECPLCLVRQ PAENAPRLLS CPHRSCGACL RQYLRIEITE SRVNICCPEC SERLNPADIR
RLLRDSPHLV AKYEEFMLRR CLAADPDCRW CPAPDCGYAV IAYGCASCPK LTCERDGCQT
EFCYHCKQIW HPNQTCDMAR QQRAQTLRVR TKHTSGLSYG QESGPADDIK PCPRCSAYII
KMNDGSCNHM TCAVCGCEFC WLCMKEISDL HYLSPSGCTF WGKKPWSRKK KILWQLGTLI
GAPVGISLIA GIAIPAMVIG IPVYVGRKIH SRYEGKKTSK HKRNLAITGG VTLSVIASPV
IAAVSVGIGV PIMLAYVYGV VPISLCRGGG CGVSTANGKG VKIEFDEDDG PITVADAWRA
LKNPSIGESS IEGLTSVLST SGSPTDGLSV MQGNYSETAS FAALSGGTLS GGVLLGGKGK
YSRLEVQADV QKEIFPKDSV SLGAISDNAS TRAMAGSIIS SYNPQDRECN NMEIQVDIEA
KPSHYQLASG SSTEDSLHVH TQMAENEEEE EEEEEEDGEQ EQTCKHQSCE QKDCIASKTW
DITLAQPESI RSDLESSDSQ SDDVPDITSD ECDSPHSQTA AACPQTPKAR GAESPSAHLS
HCAQAEGCRL DEIVKLECIE ARV
//
