ID A0A7L2BD34_9GRUI Unreviewed; 954 AA.
AC A0A7L2BD34;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000256|ARBA:ARBA00067359};
DE AltName: Full=Protein CEGP1 {ECO:0000256|ARBA:ARBA00080914};
DE AltName: Full=Scube/You {ECO:0000256|ARBA:ARBA00076123};
DE Flags: Fragment;
GN Name=Scube2_1 {ECO:0000313|EMBL:NXP56269.1};
GN ORFNames=HELFUL_R11608 {ECO:0000313|EMBL:NXP56269.1};
OS Heliornis fulica (sungrebe).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Gruiformes; Heliornithidae;
OC Heliornis.
OX NCBI_TaxID=54369 {ECO:0000313|EMBL:NXP56269.1, ECO:0000313|Proteomes:UP000590868};
RN [1] {ECO:0000313|EMBL:NXP56269.1, ECO:0000313|Proteomes:UP000590868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-001-55 {ECO:0000313|EMBL:NXP56269.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXP56269.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXP56269.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VXBZ01012526; NXP56269.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L2BD34; -.
DR OrthoDB; 4062651at2759; -.
DR Proteomes; UP000590868; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:TreeGrafter.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR FunFam; 2.10.50.10:FF:000024; signal peptide, CUB and EGF-like domain-containing protein 1; 1.
DR FunFam; 2.10.25.10:FF:000032; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1; 1.
DR FunFam; 2.10.50.10:FF:000002; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1; 1.
DR FunFam; 2.10.25.10:FF:000199; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2; 1.
DR FunFam; 2.10.25.10:FF:000237; Signal peptide, CUB domain and EGF like domain containing 2; 1.
DR FunFam; 2.10.25.10:FF:000256; Signal peptide, CUB domain and EGF like domain containing 2; 1.
DR FunFam; 2.10.25.10:FF:000028; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000030; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000035; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000037; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.60.120.290:FF:000002; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR052071; SCUB_EGF-like_domain.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 2.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000590868};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..41
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 84..120
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..358
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 764..876
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 324..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXP56269.1"
FT NON_TER 954
FT /evidence="ECO:0000313|EMBL:NXP56269.1"
SQ SEQUENCE 954 AA; 106891 MW; 58EF2A558069B564 CRC64;
DVDECALGLD DCHPDAICQN TPKLYKCMCK GGYTGEGKKC EDIDECDNDF NGGCVHECFN
IPGNYRCTCY DGFMLAHDGH NCLDTDECMF NNGGCQHICV NTVGSYECRC KEGFFLSDNQ
HTCIHRSEEG MSCMNKDHGC AHICREMPKG GVACECRPGF ELSKNQRSCI LTCNHGNGGC
QHTCDDADNG PICGCHPNYI MHVDGKTCLE REEAAVEISE GNTTAGADVD KRVKRRLLME
TCAVNNGGCD RTCKDTSTGV HCSCPVGFTL QFDGKTCKDI DECQSNNGGC DHFCKNTVGS
FDCSCRKGFK LLTDEKSCQD IDECSFERTC DHMCINHPGT FECTCNKGYA LYGFTHCGDI
NECSINNGGC QQLCVNTLGD YECLCHSNYK LHWNKKDCVE TKGPLPDNMS PKVLLHCTKS
GGSDRCFLSC SSDVQVFSDT SAIKISVTFK LNEGKCSLKK TEMFQEGLEQ MIPERHNSVM
ESFHYVNLTC SSGNKVLGTL SRPTATRETF ITADFELEMS RKEVTDTCDV RCARKKTEKR
FRKTIRTLRK TVSRDQFRIR VSGMDHEVAR KSPKLSEPQQ SCGVGQVHVG NRCGLRRSVC
EEVRDTVCPT DLCLSVHLLF SMVGFQVLCR LANITSSIMH RLKQMWCSFL DQCSPGEYSP
DGFKPCLPCP LGTYQPEAGR VSCIPCGGGL TTRHTSASLF QDCETKVQCS PGHFYNTTTH
RCIRCIVGTY QPEFGQNYCI SCPGNTTTDF DGSTNITQCK NRQCGGELGD YTGYIESPNY
PGDYPANTEC TWNINPPPKR RILIVVPEIF LPIEDECGDY LVMRKSSSSN SVTTYETCQT
YERPIAFTSR SKKLWIQFKS NEGNSAKGFQ VPYVTYDEDY QELIEDIVRD GRLYASENHQ
EILKDKKLIK ALFDVLAHPQ NYFKYTAQES REMFPRSFIR LLRSKVSRFL RPYK
//
