ID A0A7L2N0G8_9PASS Unreviewed; 1137 AA.
AC A0A7L2N0G8;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=RecQ-like DNA helicase BLM {ECO:0000256|ARBA:ARBA00073450};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase BLM {ECO:0000256|ARBA:ARBA00044542};
DE Flags: Fragment;
GN Name=Blm {ECO:0000313|EMBL:NXR65486.1};
GN ORFNames=RHASIB_R00557 {ECO:0000313|EMBL:NXR65486.1};
OS Rhadina sibilatrix.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Phylloscopidae; Rhadina.
OX NCBI_TaxID=2585818 {ECO:0000313|EMBL:NXR65486.1, ECO:0000313|Proteomes:UP000587697};
RN [1] {ECO:0000313|EMBL:NXR65486.1, ECO:0000313|Proteomes:UP000587697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-26 {ECO:0000313|EMBL:NXR65486.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXR65486.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXR65486.1}.
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DR EMBL; VWYO01016893; NXR65486.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L2N0G8; -.
DR Proteomes; UP000587697; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IEA:TreeGrafter.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR GO; GO:0000723; P:telomere maintenance; IEA:TreeGrafter.
DR CDD; cd18016; DEXHc_RecQ2_BLM; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR FunFam; 1.10.150.80:FF:000003; Bloom syndrome RecQ-like helicase; 1.
DR FunFam; 3.40.50.300:FF:000537; Bloom syndrome RecQ-like helicase; 1.
DR FunFam; 3.40.50.300:FF:000340; Bloom syndrome, RecQ helicase; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR012532; BDHCT.
DR InterPro; IPR032439; BDHCT_assoc.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF153; RECQ-LIKE DNA HELICASE BLM; 1.
DR Pfam; PF08072; BDHCT; 1.
DR Pfam; PF16204; BDHCT_assoc; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000587697};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 393..568
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 594..741
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 929..1009
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..35
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..187
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..292
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..306
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1108
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXR65486.1"
FT NON_TER 1137
FT /evidence="ECO:0000313|EMBL:NXR65486.1"
SQ SEQUENCE 1137 AA; 124346 MW; 9C44932DE62893BD CRC64;
LAGAELEEDD LDIIPPSPEE ELPAFSPSVQ SVSSVFRDSP TGGRCTAGSS EGRQEKVPTT
HPGHDPTAGD PGEAVPVAPQ LLRVMEAICE LVDAIPLQEL QALGCARALL QHRDLRRKLL
ANSVGLNQNG ISTTLPRSWK SPMEQGSRVC PAAGPGSVPS WSFSSDRNSP KSTSLPSVLS
VHSSSSSAKT NQTLDTSKQG AEEMPCPGTA ELPVPKGSGR EGASLRLSLQ SCDSSWDKTP
GTRSGNHPLT STALKAQGTA PSASPAGNSL GSTDLDFDLD PFDIDDLDED WESSVPAPAP
SLPPCQPARE GPPAKSLLSK IMSRAQGSAG GSSPAAPKPG LLMATKNHPD PVVHNPALER
FRGMKFPHSA EMMNIFHKKF GLHCFRTNQL EAINAALLGE DCFILMPTGG GKSLCYQLPA
CVSAGVTIVI SPLRSLIIDQ VQKLKTLDIA ATYLTGDRTD ADASKIYVQL SKKDPVIKLL
YVTPEKVCAS SRLMSALENL YDRKLLARFV IDEAHCVSQW GHDFRQDYKR LNMLRRKFRC
VPMMALTATA NPRVQKDILN QLEMLKPQVF TMSFNRHNLK YDVLPKKPKK VAMDCLEWIK
KYHPHDSGII YCLSRHECDT TAAILQKEGL AALAYHAGLT DSNRDLVQQK WVNQEGCQVI
CATIAFGMGI DKPDVRYVIH ASLPKSIEGY YQESGRAGRD GEMSHCLLFY SYSDVTRLRR
LILMEKDGNS HTRQTHFNNL YSMVHYCENV VECRRVQLLA YFGETNFNPT FCKDHPEVIC
DNCSRKKDYK SRNVTEDVRS IVRFVREHCG PVGRGNGKRN PGSGRYTLNM MVDIFLGSTS
AKIQSGIFGK GAAYSRHNAE RLFRKLVLDK ILDEDLYITA NDQAVAYVIL GERAQAVLDG
SLQVEFHETE SASAIRRQRA SMAKMSRREE VVKQCLSELT DTCKTLGKVF DVHYFNIFST
STLKKIAETL SSDMEVLLQI DGVTEDKLEK YGAEIIKVMD KYSECSIPED AACPGVDTAT
GSPGSLGSDG EAEDAGTTSS YFGNNTKQRR KRKQPSNSRD SKRKKTSGGG SQQFHPRGGY
SRYRRTKKLP SSKAAASSGA SSVSHSAGGM QGAAGKLAMM ALPKPKSRSF LQPSYSI
//
