ID A0A7L2WX93_PANHA Unreviewed; 729 AA.
AC A0A7L2WX93;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE SubName: Full=AFF3 protein {ECO:0000313|EMBL:NXS74029.1};
DE Flags: Fragment;
GN Name=Aff3_1 {ECO:0000313|EMBL:NXS74029.1};
GN ORFNames=PANHAL_R11737 {ECO:0000313|EMBL:NXS74029.1};
OS Pandion haliaetus (Osprey) (Falco haliaetus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC Accipitriformes; Pandionidae; Pandion.
OX NCBI_TaxID=56262 {ECO:0000313|EMBL:NXS74029.1, ECO:0000313|Proteomes:UP000580171};
RN [1] {ECO:0000313|EMBL:NXS74029.1, ECO:0000313|Proteomes:UP000580171}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-012-58 {ECO:0000313|EMBL:NXS74029.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXS74029.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXS74029.1}.
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DR EMBL; VYZV01034445; NXS74029.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L2WX93; -.
DR OrthoDB; 6382204at2759; -.
DR Proteomes; UP000580171; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:TreeGrafter.
DR GO; GO:0002151; F:G-quadruplex RNA binding; IEA:TreeGrafter.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:TreeGrafter.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF18; AF4_FMR2 FAMILY MEMBER 2; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000580171}.
FT DOMAIN 577..726
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..10
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..35
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..472
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..525
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXS74029.1"
FT NON_TER 729
FT /evidence="ECO:0000313|EMBL:NXS74029.1"
SQ SEQUENCE 729 AA; 80406 MW; B28F947640391584 CRC64;
MLEDDLKLSS DEDDNEQVNT SDMVRSSPRS SLPVPAAHAT GLAHSSGGSG SSSESESSSE
SDSDSESSSS DSECNEESRS ATPEPEPPST NKWQLDKWLN KVNPHNKTII NNQNEPHSET
SSQAQSNQQA EGPNKGKLNS ILPPTDSKDR AILSPIREKA KPRVAQKTPE AKSSKQKSPA
HNEPTSQRTT GKKQPKKVER TSSVEEYNWP KPNNTSNTPK EKDTQEPPEQ PKVRTKAAVG
KTAPRKEPRT STGLTSEKKK YRGPSKIVPK SREFIETDSS TSDSNTDQEE SLQAKVLPGC
TGSGNGVKVK DSGSNILSVS SLTSNGSNTS IDQTSNDLEE QLFSPIPIVQ NELLSPLREY
EELKSLWVKI DLSLLSRIPG QEPFETTSVK SEPREASVKH RRPSRESPTP AAEKPSTKSK
RKHKTEGLDT FVESKKQRLE DPSASCLLPP CISPIPNHRL TSTKESSGSS VKKVAKKREE
KLFPPPLSPL MDEPVHRRHS SDNSSFSQET NITNTSQTSS SSSSVSKHRK NENKSSSNPK
GICEEESHNT PTANTLLDTS HLETDIWSAM PTLSNGNSEP RRPKITFDDV LHNADYYMQE
AKKLKHKADA LLEKFGKAVN YADAALSFIE CGNAMERDPL EAKSPYTMYS ETVELIRYAM
RLKNFTGSSA TEGDKKLAVL CYRCLSLLYL RMFKLKKDHA MKYSRSLMEY FKNSSKASQA
PSPWGGNGK
//
