ID A0A7L3BGH6_9AVES Unreviewed; 251 AA.
AC A0A7L3BGH6;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE RecName: Full=Insulin-like growth factor-binding protein 7 {ECO:0000256|ARBA:ARBA00071229};
DE AltName: Full=MAC25 protein {ECO:0000256|ARBA:ARBA00078149};
DE Flags: Fragment;
GN Name=Igfbp7 {ECO:0000313|EMBL:NXT29645.1};
GN ORFNames=SYRPAR_R11075 {ECO:0000313|EMBL:NXT29645.1};
OS Syrrhaptes paradoxus (Pallas's sandgrouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Columbimorphae; Pterocliformes;
OC Pteroclidae; Syrrhaptes.
OX NCBI_TaxID=302527 {ECO:0000313|EMBL:NXT29645.1, ECO:0000313|Proteomes:UP000536260};
RN [1] {ECO:0000313|EMBL:NXT29645.1, ECO:0000313|Proteomes:UP000536260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-003-42 {ECO:0000313|EMBL:NXT29645.1};
RC TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NXT29645.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds IGF1 and IGF2 with a relatively low affinity.
CC Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
CC Acts as a ligand for CD93 to play a role in angiogenesis.
CC {ECO:0000256|ARBA:ARBA00056050}.
CC -!- SUBUNIT: May interact with VPS24/CHMP3; the relevance of such
CC interaction however remains unclear. Interacts with CD93; this
CC interaction plays a role in endothelial cells angiogenesis.
CC {ECO:0000256|ARBA:ARBA00065790}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXT29645.1}.
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DR EMBL; VZTO01026632; NXT29645.1; -; Genomic_DNA.
DR Proteomes; UP000536260; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:TreeGrafter.
DR CDD; cd00104; KAZAL_FS; 1.
DR FunFam; 2.60.40.10:FF:000763; Insulin-like growth factor binding protein 7; 1.
DR FunFam; 3.30.60.30:FF:000026; Insulin-like growth factor-binding protein 7; 1.
DR FunFam; 4.10.40.20:FF:000006; insulin-like growth factor-binding protein 7; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF19; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000536260};
KW RNA editing {ECO:0000256|ARBA:ARBA00022495};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..85
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 76..129
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 131..235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXT29645.1"
FT NON_TER 251
FT /evidence="ECO:0000313|EMBL:NXT29645.1"
SQ SEQUENCE 251 AA; 26279 MW; 288D985F3315560A CRC64;
PGPXARCPAL PPRGCPLGRV RDACGCCWQC GRGEGEACGG GGAAGGRCAP GLECVKSRQR
RKAKAPGPPP ALTAASGPPG VCLCKSRYPV CGSDGVTYSS GCQLRAASLR AQSRGEPAVS
QRSKGACEQG PSIVTPPKDI WNVTGAQIYL SCEVMGIPTP VLIWNKIIRG QYGVQRMELL
PGDRENLAIQ TRGGPEKHEV TGWVLISPLS KEDAGEYECH ASNAKGEATA SAKIHVVETL
HEIGLTKGRW C
//
