ID A0A7L3CX15_PLUSO Unreviewed; 537 AA.
AC A0A7L3CX15;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 27-NOV-2024, entry version 14.
DE SubName: Full=SOCS5 protein {ECO:0000313|EMBL:NXT47971.1};
DE Flags: Fragment;
GN Name=Socs5 {ECO:0000313|EMBL:NXT47971.1};
GN ORFNames=PLUSOC_R12424 {ECO:0000313|EMBL:NXT47971.1};
OS Pluvianellus socialis (Magellanic plover).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Charadriidae;
OC Pluvianellus.
OX NCBI_TaxID=227228 {ECO:0000313|EMBL:NXT47971.1, ECO:0000313|Proteomes:UP000519225};
RN [1] {ECO:0000313|EMBL:NXT47971.1, ECO:0000313|Proteomes:UP000519225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-012-14 {ECO:0000313|EMBL:NXT47971.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NXT47971.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXT47971.1}.
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DR EMBL; VZTS01005639; NXT47971.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3CX15; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000519225; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000519225};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 382..477
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 472..521
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 116..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXT47971.1"
FT NON_TER 537
FT /evidence="ECO:0000313|EMBL:NXT47971.1"
SQ SEQUENCE 537 AA; 61421 MW; 973DF02273DF3D99 CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNSSSCSSV KEKAIQITDL AQQQPGSPLR
ENIALQLGLS PSKNSARRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPW
GGKKKHSCST KTQSSLDTEK RFGRTRTGLQ RRERRYGVSS VHDMDAVSNR TVGSRSLRQR
LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV
SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
PKLAPGMTEL TGDKSIITPP GNCDSEEDTT TLCLQSRRQK QRQVSGESHG HISRQGAWKV
HTQIDYIHCL VPDLLQITGN PCYWGVMDRY EAEALLEGKP EGTFLLRDSA QEDYLFSVSF
RRYNRSLHAR IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPSSCMFFE PLLTVSLNRT
FPFSLQYICR AVICRCTTYD GIDDLPLPSM LQDFLKEYHY KQKVRVRWLE REPIKTK
//
