ID A0A7L3LX58_9CHAR Unreviewed; 429 AA.
AC A0A7L3LX58;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 15.
DE SubName: Full=SOCS4 protein {ECO:0000313|EMBL:NXU58392.1};
DE Flags: Fragment;
GN Name=Socs4 {ECO:0000313|EMBL:NXU58392.1};
GN ORFNames=TURVEL_R07533 {ECO:0000313|EMBL:NXU58392.1};
OS Turnix velox (Little buttonquail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Turnicidae;
OC Turnix.
OX NCBI_TaxID=2529409 {ECO:0000313|EMBL:NXU58392.1, ECO:0000313|Proteomes:UP000582182};
RN [1] {ECO:0000313|EMBL:NXU58392.1, ECO:0000313|Proteomes:UP000582182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-029-46 {ECO:0000313|EMBL:NXU58392.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXU58392.1}.
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DR EMBL; VZTY01031909; NXU58392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3LX58; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000582182; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000582182};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 275..370
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 365..414
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXU58392.1"
FT NON_TER 429
FT /evidence="ECO:0000313|EMBL:NXU58392.1"
SQ SEQUENCE 429 AA; 49022 MW; CD46FBDAA86D7D41 CRC64;
MAENKDSNIK NADVRPKSSR SRSADRKDGY VWSGKKLSWS KKSEHSSDAE TGSSGVGRSG
SSLRSQERKY SCSSIELDLD RSCGHRFLGR SLKQKLQDAV GQCFPIKNCS SRHASGLPAK
RKIHISELML DKCPFPPRSD LAFRWHLIKR HTAPLSPKAE DWIIADLSQQ EEKEDELRAD
ELTNGGMESP SPSCDFPEGS SSRRDSRCEV GRDESDMDSD DEVVTLCTSS RKRNKPRWET
DDELLRMETP PKYHTQIDYV HCLVPDLLQI NNNPCYWGVM DKYAAEALLE GKPEGTFLLR
DSAQEDYLFS VSFRRYSRSL HARIEQWNHN FSFDAHDPCV FHSPDITGLL EHYKDPSSCM
FFEPLLSTPL NRTFPFSLQH LCRTVICNCT TYDGIDALPI PPSVKLYLKE YHYKSKVRVL
RIDVPEQQS
//
