ID A0A7L3M3E7_9PASS Unreviewed; 87 AA.
AC A0A7L3M3E7;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 15.
DE SubName: Full=GLUC protein {ECO:0000313|EMBL:NXU60642.1};
DE Flags: Fragment;
GN Name=Gcg {ECO:0000313|EMBL:NXU60642.1};
GN ORFNames=HORVUL_R08837 {ECO:0000313|EMBL:NXU60642.1};
OS Horornis vulcanius.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Scotocercidae; Horornis.
OX NCBI_TaxID=2585811 {ECO:0000313|EMBL:NXU60642.1, ECO:0000313|Proteomes:UP000558460};
RN [1] {ECO:0000313|EMBL:NXU60642.1, ECO:0000313|Proteomes:UP000558460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-029-69 {ECO:0000313|EMBL:NXU60642.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXU60642.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXU60642.1}.
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DR EMBL; VZUA01008929; NXU60642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3M3E7; -.
DR OrthoDB; 9904258at2759; -.
DR Proteomes; UP000558460; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031769; F:glucagon receptor binding; IEA:TreeGrafter.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:TreeGrafter.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:TreeGrafter.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:TreeGrafter.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000558460};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..87
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029549173"
FT DOMAIN 55..77
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 27..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXU60642.1"
FT NON_TER 87
FT /evidence="ECO:0000313|EMBL:NXU60642.1"
SQ SEQUENCE 87 AA; 10218 MW; 5EDC5BD3EBB0C5BC CRC64;
MKMKSIYFVA GLLLMIVQGS WQNPLQDTEE KSRSFKASHS EPIEESRQLN EVKRHSQGTF
TSDYTKYLDT RRAQDFVQWL MSTKRNG
//
