ID A0A7L3MJA7_9PASS Unreviewed; 308 AA.
AC A0A7L3MJA7;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 18.
DE RecName: Full=CCN family member 3 {ECO:0000256|ARBA:ARBA00039944};
DE AltName: Full=Cellular communication network factor 3 {ECO:0000256|ARBA:ARBA00042352};
DE AltName: Full=Nephroblastoma-overexpressed gene protein {ECO:0000256|ARBA:ARBA00082093};
DE AltName: Full=Protein NOV {ECO:0000256|ARBA:ARBA00076570};
DE Flags: Fragment;
GN Name=Nov {ECO:0000313|EMBL:NXU66584.1};
GN ORFNames=HORVUL_R00068 {ECO:0000313|EMBL:NXU66584.1};
OS Horornis vulcanius.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Scotocercidae; Horornis.
OX NCBI_TaxID=2585811 {ECO:0000313|EMBL:NXU66584.1, ECO:0000313|Proteomes:UP000558460};
RN [1] {ECO:0000313|EMBL:NXU66584.1, ECO:0000313|Proteomes:UP000558460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-029-69 {ECO:0000313|EMBL:NXU66584.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXU66584.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXU66584.1}.
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DR EMBL; VZUA01105519; NXU66584.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3MJA7; -.
DR OrthoDB; 365605at2759; -.
DR Proteomes; UP000558460; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:TreeGrafter.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:TreeGrafter.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:TreeGrafter.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IEA:TreeGrafter.
DR GO; GO:0051240; P:positive regulation of multicellular organismal process; IEA:UniProtKB-ARBA.
DR FunFam; 2.20.100.10:FF:000165; CCN family member 3; 1.
DR FunFam; 2.10.70.10:FF:000015; CYR61 isoform 1; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR050941; CCN.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF8; CCN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000558460};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..58
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 61..127
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 215..289
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXU66584.1"
FT NON_TER 308
FT /evidence="ECO:0000313|EMBL:NXU66584.1"
SQ SEQUENCE 308 AA; 33937 MW; 509F3982556460AB CRC64;
PRCAPGVPAV LDGCSCCLVC ARQRGERCSA LLPCDESSGL YCDRGPEDGA AAGICMVLEG
DNCVFDGMIY RNGETFQPSC KYQCTCRDGQ IGCLPRCNLD LLLPGPDCPF PRKVEVPGEC
CEKWVCDPDD EVILGGFAMA AYRQEATLGI DVSDSSANCI EQTTEWSACS KSCGMGFSTR
VTNRNQQCEM VKQTRLCLIR PCENEESSDK KGKKCIRTKK SVRAVRYEYR NCSSVQTYRP
RYCGLCSDGR CCTPHSTKTI QVEFRCPQGK VLKKPMMLIN TCVCHNNCPQ SNVVFFQPLD
ATSSEAKI
//
