ID A0A7L3N5J3_9AVES Unreviewed; 156 AA.
AC A0A7L3N5J3;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 08-OCT-2025, entry version 15.
DE RecName: Full=Transcription factor HES-5 {ECO:0000256|ARBA:ARBA00072975};
DE AltName: Full=Hairy and enhancer of split 5 {ECO:0000256|ARBA:ARBA00081413};
DE Flags: Fragment;
GN Name=Hes5_0 {ECO:0000313|EMBL:NXU74237.1};
GN ORFNames=OREMEL_R07891 {ECO:0000313|EMBL:NXU74237.1};
OS Oreotrochilus melanogaster.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Strisores; Apodiformes;
OC Trochilidae; Oreotrochilus.
OX NCBI_TaxID=689266 {ECO:0000313|EMBL:NXU74237.1, ECO:0000313|Proteomes:UP000579904};
RN [1] {ECO:0000313|EMBL:NXU74237.1, ECO:0000313|Proteomes:UP000579904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0002 {ECO:0000313|EMBL:NXU74237.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor of genes that require a bHLH
CC protein for their transcription. Plays an important role as
CC neurogenesis negative regulator. {ECO:0000256|ARBA:ARBA00060201}.
CC -!- SUBUNIT: Transcription repression requires formation of a complex with
CC a corepressor protein of the Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00023791}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXU74237.1}.
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DR EMBL; VZUB01003408; NXU74237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3N5J3; -.
DR OrthoDB; 6085656at2759; -.
DR Proteomes; UP000579904; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProtKB-ARBA.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:UniProtKB-ARBA.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11461; bHLH-O_HES5; 1.
DR FunFam; 4.10.280.10:FF:000033; Transcription factor HES-5; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000579904};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 16..72
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 86..118
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 127..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXU74237.1"
FT NON_TER 156
FT /evidence="ECO:0000313|EMBL:NXU74237.1"
SQ SEQUENCE 156 AA; 17856 MW; 56BA768F66F218E2 CRC64;
MAPSTLSLEI LTPKEKNRLR KPIVEKLRRD RINSSIEQLK LLLEKEFQRH QPNSKLEKAD
ILEMTVSYLK YSRAFAASAK SLQQDYCEGY AWCLKEALQF LSLHSASTET RMKLICHFQR
SQAVPKDSGS SLPASTHQPP AKQAALKPSC SLWRPW
//
