ID A0A7L3QK65_9SYLV Unreviewed; 229 AA.
AC A0A7L3QK65;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=uridine/cytidine kinase {ECO:0000256|ARBA:ARBA00012137};
DE EC=2.7.1.48 {ECO:0000256|ARBA:ARBA00012137};
DE Flags: Fragment;
GN Name=Uck2 {ECO:0000313|EMBL:NXV02151.1};
GN ORFNames=CETCET_R11287 {ECO:0000313|EMBL:NXV02151.1};
OS Cettia cetti.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Sylviidae; Acrocephalinae; Cettia.
OX NCBI_TaxID=68486 {ECO:0000313|EMBL:NXV02151.1, ECO:0000313|Proteomes:UP000524451};
RN [1] {ECO:0000313|EMBL:NXV02151.1, ECO:0000313|Proteomes:UP000524451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0056 {ECO:0000313|EMBL:NXV02151.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NXV02151.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cytidine + ATP = CMP + ADP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00047436};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine + ATP = UMP + ADP + H(+); Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00048909};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3. {ECO:0000256|ARBA:ARBA00004784}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1. {ECO:0000256|ARBA:ARBA00004690}.
CC -!- SIMILARITY: Belongs to the uridine kinase family.
CC {ECO:0000256|ARBA:ARBA00005408}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXV02151.1}.
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DR EMBL; VZUI01043348; NXV02151.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3QK65; -.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR Proteomes; UP000524451; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd02023; UMPK; 1.
DR FunFam; 3.40.50.300:FF:000297; Uridine-cytidine kinase 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR000764; Uridine_kinase-like.
DR NCBIfam; NF004018; PRK05480.1; 1.
DR PANTHER; PTHR10285; URIDINE KINASE; 1.
DR Pfam; PF00485; PRK; 1.
DR PRINTS; PR00988; URIDINKINASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:NXV02151.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000524451};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..185
FT /note="Phosphoribulokinase/uridine kinase"
FT /evidence="ECO:0000259|Pfam:PF00485"
FT REGION 207..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXV02151.1"
FT NON_TER 229
FT /evidence="ECO:0000313|EMBL:NXV02151.1"
SQ SEQUENCE 229 AA; 26278 MW; C43D4232796143F1 CRC64;
QSSVCSKIVQ LLGQNEVDYR QKQVVIVSQD SFYRVLTSEQ KSKALKGQFN FDHPDAFDNE
LIVKTLKEIT EGKTVQIPVY DFVSHSRKEE TVTVYPADVV LFEGILAFYS QEVRDLFRMK
LFVDTDADTR LSRRVLRDIS ERGRDLEQIL SQYITFVKPA FEEFCLPTKK YADVIIPRGA
DNEVAINLIV QHIQDILNGG LSKRQSNGYL NGYTPPRQRQ PSESSSRPH
//
