ID A0A7L3QU33_9SYLV Unreviewed; 117 AA.
AC A0A7L3QU33;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11 {ECO:0000256|ARBA:ARBA00019621, ECO:0000256|RuleBase:RU364147};
DE AltName: Full=Mediator complex subunit 11 {ECO:0000256|ARBA:ARBA00032011, ECO:0000256|RuleBase:RU364147};
DE Flags: Fragment;
GN Name=Med11 {ECO:0000313|EMBL:NXV06986.1};
GN Synonyms=MED11 {ECO:0000256|RuleBase:RU364147};
GN ORFNames=CETCET_R15026 {ECO:0000313|EMBL:NXV06986.1};
OS Cettia cetti.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Sylviidae; Acrocephalinae; Cettia.
OX NCBI_TaxID=68486 {ECO:0000313|EMBL:NXV06986.1, ECO:0000313|Proteomes:UP000524451};
RN [1] {ECO:0000313|EMBL:NXV06986.1, ECO:0000313|Proteomes:UP000524451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0056 {ECO:0000313|EMBL:NXV06986.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NXV06986.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional pre-initiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364147}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000256|ARBA:ARBA00008186, ECO:0000256|RuleBase:RU364147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXV06986.1}.
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DR EMBL; VZUI01067734; NXV06986.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3QU33; -.
DR Proteomes; UP000524451; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR FunFam; 1.10.287.3490:FF:000001; Mediator of RNA polymerase II transcription subunit 11; 1.
DR Gene3D; 1.10.287.3490; -; 1.
DR InterPro; IPR019404; Mediator_Med11.
DR PANTHER; PTHR22890; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11; 1.
DR Pfam; PF10280; Med11; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364147};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364147};
KW Reference proteome {ECO:0000313|Proteomes:UP000524451};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364147};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364147}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXV06986.1"
FT NON_TER 117
FT /evidence="ECO:0000313|EMBL:NXV06986.1"
SQ SEQUENCE 117 AA; 12911 MW; ED821189DB45AB89 CRC64;
MAGFGVANER LRALEELERE IGASLQSAGS VILELSKEKP QERHLDRQAA QFGAAVAKVE
AELSAQIRYL TQVATGQPHE GSSYAARKSC QLALNRLDYA RRRLAELARA CELMLEQ
//