ID A0A7L4C6E5_9AVES Unreviewed; 924 AA.
AC A0A7L4C6E5;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 10-JUN-2026, entry version 17.
DE RecName: Full=Rho GTPase-activating protein 20 {ECO:0000256|ARBA:ARBA00070254};
DE AltName: Full=Rho-type GTPase-activating protein 20 {ECO:0000256|ARBA:ARBA00083374};
DE Flags: Fragment;
GN Name=Arhgap20_0 {ECO:0000313|EMBL:NXW45371.1};
GN ORFNames=NYCLEU_R10819 {ECO:0000313|EMBL:NXW45371.1};
OS Nyctiprogne leucopyga.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Strisores; Caprimulgiformes;
OC Caprimulgidae; Chordeilinae; Nyctiprogne.
OX NCBI_TaxID=382315 {ECO:0000313|EMBL:NXW45371.1, ECO:0000313|Proteomes:UP000551823};
RN [1] {ECO:0000313|EMBL:NXW45371.1, ECO:0000313|Proteomes:UP000551823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-005-01 {ECO:0000313|EMBL:NXW45371.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000256|ARBA:ARBA00055252}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXW45371.1}.
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DR EMBL; VZZU01000943; NXW45371.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L4C6E5; -.
DR Proteomes; UP000551823; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd17115; RA_RHG20; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR FunFam; 2.30.29.30:FF:000217; Rho GTPase activating protein 20; 1.
DR FunFam; 1.10.555.10:FF:000025; Rho GTPase-activating protein 20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR047888; ARHGAP20_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF22286; RHG20_PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000551823}.
FT DOMAIN 195..313
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 364..550
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..25
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..595
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..630
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXW45371.1"
FT NON_TER 924
FT /evidence="ECO:0000313|EMBL:NXW45371.1"
SQ SEQUENCE 924 AA; 102850 MW; 685783554037A16F CRC64;
MDVMSPQQEH LGPGRSSSVS GESRVFAAPD SKKKMKSLAQ RRQSAPSLIF VKALHRSRSV
SREGCFSPIS PEACPLVQSF MCHNRTFILD GHVQLKTGLQ TQERHLFLFT DLLVVAKSKS
HSHFKLKCQA RLCEMWTAFC TEEVCEGSTD PERSFVLGWP TTNCVANFRS AEQKETWLSF
LQSRIREEKE KDYPKSIPLK IIAKDVGTCA YSKTLSVTNV DTANDVILMA LQQLGINGSE
KDYKLWVISG REDAPYPLIG HEYPFGIKMS HIRDAMPHGS KHCACPRQLQ GSFLSEQLPQ
ELQCQFVLKP SRLPVCQQLN DLSQKSFKRK RSIINWAFWR GPGTHLDHAP LSSTSAAPGK
LFGLLLTAIC EDDNLPKPLL DMLSLLYQEG PSTEGIFRRS GSAKTCKELK EKLDSGAEVD
LACESIFVTA SLFKDFLRNI PGSILSSQLC DKWVSVMDQG NNEEKIKSIQ RLIEQLPRAN
VVLLRYIFGV LHGIEMRSEE NQMNAFNLAV CIAPSLLWPP ISSTPEIESE FTKKISSLVQ
FLTENCCRIF GEEITSLFGE IMMTCKRENG SDAASLHLND SSYDSLENEV NDEADSSSSD
WIKNRDQDNR SRESVFTLSD GDSEQTEVDE IQSKTKSKQL TISVDVHRKF SSQENSENES
LCSNALSFSS AATSGALKTL RRHRRSSEPA IGLLAPSVAR IGDGREKATR KASCDVVLSH
EDEDYLRQLR SLQMEGQKLI NQSLIIGINV GKSDNTNQNV EKKDLPHCLM PPMPERLNIC
SGFSSSSLSS PGTSPSVSSM SSLDSAFSQF SDQSVFTPTE TSSPFDSTFQ SLKKHEDTAT
EVADDYLVTP TKVPPSPQPT DTLAEGGFME RNSRPAPLKP TDGVDGYLIK PDIQPLPLKV
PGRDRLHDPR SKRRSRRALQ QSKV
//
