ID A0A7L7KR11_9BACT Unreviewed; 343 AA.
AC A0A7L7KR11;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 02-APR-2025, entry version 15.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465, ECO:0000256|RuleBase:RU362068};
DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014, ECO:0000256|RuleBase:RU362068};
DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024, ECO:0000256|RuleBase:RU362068};
GN ORFNames=G4Z02_02450 {ECO:0000313|EMBL:QMS84656.1};
OS Candidatus Xianfuyuplasma coldseepsis.
OC Bacteria; Bacillati; Mycoplasmatota; Candidatus Izimaplasma;
OC Candidatus Izemoplasmatales; Candidatus Izemoplasmataceae;
OC Candidatus Xianfuyuplasma.
OX NCBI_TaxID=2782163 {ECO:0000313|EMBL:QMS84656.1, ECO:0000313|Proteomes:UP000514720};
RN [1] {ECO:0000313|EMBL:QMS84656.1, ECO:0000313|Proteomes:UP000514720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zrk13 {ECO:0000313|Proteomes:UP000514720};
RA Zheng R.K., Sun C.M.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate into
CC pantoic acid. {ECO:0000256|ARBA:ARBA00002919,
CC ECO:0000256|RuleBase:RU362068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+);
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00048793,
CC ECO:0000256|RuleBase:RU362068};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994, ECO:0000256|RuleBase:RU362068}.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870, ECO:0000256|RuleBase:RU362068}.
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DR EMBL; CP048914; QMS84656.1; -; Genomic_DNA.
DR RefSeq; WP_258878275.1; NZ_CP048914.1.
DR AlphaFoldDB; A0A7L7KR11; -.
DR KEGG; xcl:G4Z02_02450; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000514720; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00745; apbA_panE; 1.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|RuleBase:RU362068};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362068};
KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655,
KW ECO:0000256|RuleBase:RU362068};
KW Reference proteome {ECO:0000313|Proteomes:UP000514720}.
FT DOMAIN 3..139
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 179..321
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 343 AA; 37703 MW; FD056F4EFE9DE418 CRC64;
MRVAIYGAGA MGTVLGAFIT KAGYEVDLIN RNKDHVRGLQ EHGAQIQGTL SMSQDVTALL
PEEMTGLYDV ILLMTKQRHN QEIVTFLQPY LAQDGVLCTL QNGIPEPLIA SIIGDERTIG
ATMSWGATFI GGGVVELTTE PSRETLTFSI GSYSDKRPQH FDYVVTLLHT MGHVTIEDNF
IGARWSKLLI NAAYSGLSVV TGATFGELNK NRTTRTIALG AMKECIDVAK ASNLMIEPLQ
GKDVVKLMDY NNPFKKQFSL FLLPIAMRKH KNIKSSMLRD LARGYTTEID AINGVVCDAG
DQVGIETPIN DLIVSIVHEI ETNKRASSWD NIKDFDMMNM KGA
//
