ID A0A7M4G378_CROPO Unreviewed; 435 AA.
AC A0A7M4G378;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|Ensembl:ENSCPRP00005026943.1};
GN Name=SOCS4 {ECO:0000313|Ensembl:ENSCPRP00005026943.1};
OS Crocodylus porosus (Saltwater crocodile) (Estuarine crocodile).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Longirostres; Crocodylidae;
OC Crocodylus.
OX NCBI_TaxID=8502 {ECO:0000313|Ensembl:ENSCPRP00005026943.1, ECO:0000313|Proteomes:UP000594220};
RN [1] {ECO:0000313|Ensembl:ENSCPRP00005026943.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCPRP00005026943.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_019406517.1; XM_019550972.1.
DR RefSeq; XP_019406518.1; XM_019550973.1.
DR RefSeq; XP_019406519.1; XM_019550974.1.
DR RefSeq; XP_019406520.1; XM_019550975.1.
DR AlphaFoldDB; A0A7M4G378; -.
DR Ensembl; ENSCPRT00005031471.1; ENSCPRP00005026943.1; ENSCPRG00005018664.1.
DR GeneID; 109320721; -.
DR KEGG; cpoo:109320721; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000161456; -.
DR OMA; RINNNPC; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000594220; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000594220};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 281..376
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 371..420
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 49750 MW; 4ADF0464848D925C CRC64;
MAENKESNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS RKSEHCSEAE TVSSLGKPAA
GLRNQERKHS CSSGELELDR SCGHRFLGRS FKQKLQDAVG QCFPLKNCGS RHSSMLPSKR
KIHISELMLD KCPFPPRSEL ASRWHLIKRH TAPISQKPED WMVADLSQSE ERDNQPRDGE
SFSGGVSSLQ SCDILDDDSC NCDPRAESGV SQVLKNEKDE SDMDSDDEVI TLCTSSRKRN
KPKWETDDEL LQLEKPPKYH TQIDYVHCLV PDLLQINNNP CYWGVMDKYA AEALLEGKPE
GTFLLRDSAQ EDYLFSVSFR RYSRSLHARI EQWNHNFSFD AHDPCVFHSP DITGLLEHYK
DPSSCMFFEP LLSTPLHRTF PFSLQHICRT VICNCTTYDG IDALPVPPSV KLYLKEYHYK
SKVRVLRIDV PEQQS
//
