ID   A0A7M7K930_VARDE        Unreviewed;       340 AA.
AC   A0A7M7K930;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   28-JAN-2026, entry version 15.
DE   RecName: Full=BBSome complex member BBS5 PH domain-containing protein {ECO:0000259|SMART:SM00683};
OS   Varroa destructor (Honeybee mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Mesostigmata; Gamasina; Dermanyssoidea; Varroidae; Varroa.
OX   NCBI_TaxID=109461 {ECO:0000313|EnsemblMetazoa:XP_022662257, ECO:0000313|Proteomes:UP000594260};
RN   [1] {ECO:0000313|EnsemblMetazoa:XP_022662257}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JAN-2021) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriolar satellite
CC       {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family.
CC       {ECO:0000256|ARBA:ARBA00005822}.
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DR   RefSeq; XP_022662257.1; XM_022806522.1.
DR   AlphaFoldDB; A0A7M7K930; -.
DR   EnsemblMetazoa; XM_022806522; XP_022662257; LOC111250780.
DR   GeneID; 111250780; -.
DR   CTD; 129880; -.
DR   Proteomes; UP000594260; Unplaced.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000594260}.
FT   DOMAIN          17..71
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          147..201
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   340 AA;  38346 MW;  7D86ED6779E80C4D CRC64;
     MTSSTFSLFE LAFGSVEQLL DKLESVEDTK GNPGERGKIF ISNMRLIWQS HTKPRVNLTV
     GWACVTGISS RSVNSALKGL TEALYLMTRL NNTRFEFIFT NLMSGTPRLV ASVLNVYKTY
     NATRLYRELK LRSAIIHNRA LKVLQLERII SKINGVWNLS SDQGNLGTFY VTNVRIVWHA
     NLNENFNVSL PYIQVASLRS RESKFGMALV IETTEWSGGY LLGFKIDPPE KLKEVLKELR
     SVCKVHREKP IWGVDETTLQ TTQKATMELI NEEGSIGMPT LIEDDEVSQQ DIPPDLLAAY
     YVDGGLEEDR QIVYAEELGL AVEALTEGYT LKSLWEVIPS
//