ID A0A7N0R8Y4_KALFE Unreviewed; 1095 AA.
AC A0A7N0R8Y4;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146};
DE EC=7.2.2.10 {ECO:0000256|RuleBase:RU361146};
OS Kalanchoe fedtschenkoi (Lavender scallops) (South American air plant).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC Saxifragales; Crassulaceae; Kalanchoe.
OX NCBI_TaxID=63787 {ECO:0000313|EnsemblPlants:Kaladp0001s0311.6.v1.1, ECO:0000313|Proteomes:UP000594263};
RN [1] {ECO:0000313|EnsemblPlants:Kaladp0001s0311.6.v1.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of
CC calcium. {ECO:0000256|RuleBase:RU361146}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+);
CC Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00048694,
CC ECO:0000256|RuleBase:RU361146};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004127}. Membrane
CC {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361146}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIB subfamily. {ECO:0000256|ARBA:ARBA00006124,
CC ECO:0000256|RuleBase:RU361146}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361146}.
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DR AlphaFoldDB; A0A7N0R8Y4; -.
DR EnsemblPlants; Kaladp0001s0311.2.v1.1; Kaladp0001s0311.2.v1.1; Kaladp0001s0311.v1.1.
DR EnsemblPlants; Kaladp0001s0311.3.v1.1; Kaladp0001s0311.3.v1.1; Kaladp0001s0311.v1.1.
DR EnsemblPlants; Kaladp0001s0311.4.v1.1; Kaladp0001s0311.4.v1.1; Kaladp0001s0311.v1.1.
DR EnsemblPlants; Kaladp0001s0311.5.v1.1; Kaladp0001s0311.5.v1.1; Kaladp0001s0311.v1.1.
DR EnsemblPlants; Kaladp0001s0311.6.v1.1; Kaladp0001s0311.6.v1.1; Kaladp0001s0311.v1.1.
DR Gramene; Kaladp0001s0311.2.v1.1; Kaladp0001s0311.2.v1.1; Kaladp0001s0311.v1.1.
DR Gramene; Kaladp0001s0311.3.v1.1; Kaladp0001s0311.3.v1.1; Kaladp0001s0311.v1.1.
DR Gramene; Kaladp0001s0311.4.v1.1; Kaladp0001s0311.4.v1.1; Kaladp0001s0311.v1.1.
DR Gramene; Kaladp0001s0311.5.v1.1; Kaladp0001s0311.5.v1.1; Kaladp0001s0311.v1.1.
DR Gramene; Kaladp0001s0311.6.v1.1; Kaladp0001s0311.6.v1.1; Kaladp0001s0311.v1.1.
DR OMA; QLAVTFM; -.
DR Proteomes; UP000594263; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR CDD; cd02081; P-type_ATPase_Ca_PMCA-like; 1.
DR FunFam; 1.20.1110.10:FF:000036; Calcium-transporting ATPase; 1.
DR FunFam; 1.20.1110.10:FF:000039; Calcium-transporting ATPase; 1.
DR FunFam; 1.20.5.170:FF:000029; Calcium-transporting ATPase; 1.
DR FunFam; 2.70.150.10:FF:000006; Calcium-transporting ATPase; 1.
DR FunFam; 3.40.1110.10:FF:000013; Calcium-transporting ATPase; 1.
DR FunFam; 3.40.50.1000:FF:000011; Calcium-transporting ATPase; 1.
DR FunFam; 1.20.1110.10:FF:000097; Calcium-transporting ATPase 9 plasma membrane-type; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR024750; Ca_ATPase_N_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006408; P-type_ATPase_IIB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01517; ATPase-IIB_Ca; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR24093:SF369; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24093; CATION TRANSPORTING ATPASE; 1.
DR Pfam; PF12515; CaATP_NAI; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361146};
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU361146};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU361146};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361146}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361146};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361146};
KW Reference proteome {ECO:0000313|Proteomes:UP000594263};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361146};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361146};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361146}.
FT TRANSMEM 186..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 223..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 373..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 424..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 854..876
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 921..940
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 961..977
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 997..1018
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 1030..1051
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT DOMAIN 134..211
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 120268 MW; D81D1AFD2CD26D92 CRC64;
MSEFKSSPYR RRHDLESGTS SVDEDEVPFS VFDITSTKNA STERLKRWRQ AALVLNASRR
FRYTLDLRRE EEKKQAIRRI RAHAEALRAA ELFKKAGEQA TDSGDHKVST TPIGDFGISQ
EELALLTREN DISALQQLGG VKGLSDMLKT SIDKGISGDE DDILKRKNAY GSNTYPRKKG
RSFWMFLWEA WQDLTLIILM VAAAFSLGLG IKTEGIKEGW YDGGSIAFAV ILVIVVTAIS
DYRQSLQFQN LNDEKRNIHL KVIRGGRRVE ISIFDIVVGD VIPLNIGDQV PADGILISGH
SLAIDESSMT GESKIVHKDS KAPFLMSGCK VADGSGVMLV TSVGINTEWG MLMASISEDT
GEETPLQVRL NGVATFIGIV GLSVAVLVLV VLLARYFTGT SKNEDDTVQY VKGKMSVSKT
IDGVIKIITV AVTIVVVAVP EGLPLAVTLT LAYSMRKMMA DKALVRRLSA CETMGSATTI
CSDKTGTLTL NQMTVVASYV GERKSEPPYS SSLFPPRVCS LLIEGIAQNT TGSVFRPEGG
GEVEISGSPT EKAILEWGVK LGMNFEIARS ESTILHVFPF NSEKKRGGVA VRRPDSEVHV
HWKGAAEIVL GCCTGYFDEN GNLVKMDEEK EMFFKQSIED MAAQSLRCVA IAYRPCDPEK
VPTDEELLSK WELPEDDLVL LAIVGIKDPC RPGVKDAVQL CQNAGVKVRM VTGDNVKTAR
AIAMECGILK SDEDATEPNL IEGRAFRALS DAQRDDIADK ISVMGRSSPN DKLLLVQALR
RKGHVVAVTG DGTNDAPALH EADIGLAMGI AGTEVAKESS DIIILDDNFS SVVKVVRWGR
SVYANIQKFI QFQLTVNVAA LIINVVAAVS SGFVPLNAVQ LLWVNLIMDT LGALALATEP
PTDHLMERPP VGRREPLITN VMWRNLLIQA IYQVTVLLIL NFRGRSLLGL EHESKERANK
LKNTLIFNAF VLCQIFNEFN ARKPDEVNVF QGVTKNRLFM GIIAVTVVLQ IIIVEFLGKF
ASTTKLNWKY WLISVAIGIV SWPLAALGKL LPVPETPFSD YFTSAYRSFM RVFRRPKRDS
SDPGKVGEAA RENHS
//
