ID   A0A7N0TV30_KALFE        Unreviewed;       437 AA.
AC   A0A7N0TV30;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   05-FEB-2025, entry version 13.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000256|HAMAP-Rule:MF_03004, ECO:0000256|PIRNR:PIRNR016255};
DE            Short=eIF3e {ECO:0000256|HAMAP-Rule:MF_03004};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000256|HAMAP-Rule:MF_03004};
OS   Kalanchoe fedtschenkoi (Lavender scallops) (South American air plant).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Saxifragales; Crassulaceae; Kalanchoe.
OX   NCBI_TaxID=63787 {ECO:0000313|EnsemblPlants:Kaladp0046s0179.1.v1.1, ECO:0000313|Proteomes:UP000594263};
RN   [1] {ECO:0000313|EnsemblPlants:Kaladp0046s0179.1.v1.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JAN-2021) to UniProtKB.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000256|HAMAP-Rule:MF_03004}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03004,
CC       ECO:0000256|PIRNR:PIRNR016255}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03004,
CC       ECO:0000256|PIRNR:PIRNR016255}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000256|HAMAP-
CC       Rule:MF_03004, ECO:0000256|PIRNR:PIRNR016255}.
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DR   AlphaFoldDB; A0A7N0TV30; -.
DR   EnsemblPlants; Kaladp0046s0179.1.v1.1; Kaladp0046s0179.1.v1.1; Kaladp0046s0179.v1.1.
DR   Gramene; Kaladp0046s0179.1.v1.1; Kaladp0046s0179.1.v1.1; Kaladp0046s0179.v1.1.
DR   OMA; NCPWILR; -.
DR   Proteomes; UP000594263; Unplaced.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd21378; eIF3E; 1.
DR   FunFam; 1.25.40.570:FF:000020; Eukaryotic translation initiation factor 3 subunit E; 1.
DR   Gene3D; 1.25.40.570; -; 1.
DR   HAMAP; MF_03004; eIF3e; 1.
DR   InterPro; IPR016650; eIF3e.
DR   InterPro; IPR019010; eIF3e_N.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10317; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E; 1.
DR   Pfam; PF09440; eIF3_N; 1.
DR   Pfam; PF21357; EIF3E_C; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PIRSF; PIRSF016255; eIF3e_su6; 1.
DR   SMART; SM01186; eIF3_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03004};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW   Rule:MF_03004};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_03004}; Reference proteome {ECO:0000313|Proteomes:UP000594263}.
FT   DOMAIN          219..403
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
SQ   SEQUENCE   437 AA;  51288 MW;  22BACC4ACA190431 CRC64;
     MANYDLTPRI VPNLDRHLVF PLLEFLQERQ MYPDEQILKA KIELLNKTNM VDYAMDIHRS
     LYHTEDVPQD MVERRAEVVS RLKALEESAA PLISFLQNPS AVQELKADKL YNIQMLNDRY
     QIGPDQIEAL YQYAKFQFEC GNYSGAADYL YQYRALCANP DKSLSALWGK LAAEVLMQNW
     DIALEELNRL KEIIDSKNFP SPLNQVQCRI WLMHWSLFIF FNNENGRSQI IDLFNQDKYL
     NAIQTNAPHL LRYLATAFIV NKRRRPQFKE FIRVVQQEQH SYKDPITEFL ACVYVNYDFD
     GAQRKMKECE GVILNDPFLG KRVEEGSFST VPLCDEFLEN ARLFIFETYC RIHQRIDMRV
     FAEKLNLNYE EAERWIMNLI RNSKLDAKID TQTGTVIMDP NKPNVYEQLI DHTKALSGRT
     YKLVSQVLEH AQPQPAR
//