ID A0A7N4NLB7_SARHA Unreviewed; 539 AA.
AC A0A7N4NLB7;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSSHAP00000024795.1};
GN Name=SOCS5 {ECO:0000313|Ensembl:ENSSHAP00000024795.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000024795.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000024795.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000024795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_031806289.1; XM_031950429.1.
DR RefSeq; XP_031806290.1; XM_031950430.1.
DR RefSeq; XP_031806291.1; XM_031950431.1.
DR RefSeq; XP_031806292.1; XM_031950432.1.
DR RefSeq; XP_031806293.1; XM_031950433.1.
DR AlphaFoldDB; A0A7N4NLB7; -.
DR Ensembl; ENSSHAT00000024669.1; ENSSHAP00000024201.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000029126.1; ENSSHAP00000042864.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000029596.1; ENSSHAP00000040807.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000032334.1; ENSSHAP00000038028.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000035577.1; ENSSHAP00000038600.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000049531.1; ENSSHAP00000024795.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000051238.1; ENSSHAP00000044050.1; ENSSHAG00000029401.1.
DR Ensembl; ENSSHAT00000052904.1; ENSSHAP00000045963.1; ENSSHAG00000029401.1.
DR GeneID; 100920946; -.
DR KEGG; shr:100920946; -.
DR CTD; 9655; -.
DR GeneTree; ENSGT00940000159000; -.
DR OMA; CQNLFNH; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0097699; P:vascular endothelial cell response to fluid shear stress; IEA:Ensembl.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 384..479
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 474..523
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 117..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 61471 MW; B2C3FC914B3E2372 CRC64;
MDKVGKMWNN FKYRCQNLFN HEGGNSSENI DVNSNKCLSV KERNISVGDL TPQQQSSPLR
ENVALQLELS PSKNSSRRNQ NCAADIPQIV EISIEKENDS CLTTTGTRLA RRDSYSRHAP
WGGKKKHSCS TKTQSSLDTE KRFGRPRSGL QRRERRYGVS SVHDMESVSS RTVGSRSLRQ
RLQDTVGLCF PMRTYNKQAK PLFSNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP
VSPHSTFFDT FDPSLVSTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPLYKL
GPKLAPGMTE MTGENAATPQ GGCDSEEDAP TLCLQARRQK QRQGSGDSHG HGHGSRQGAW
KVHTQIDYIH CLVPDLLQIT GNPCYWGVMD RYEAEALLEG KPEGTFLLRD SAQEDYLFSV
SFRRYNRSLH ARIEQWNHNF SFDAHDPCVF HSSTVTGLLE HYKDPSSCMF FEPLLTVSLN
RTFPFSLQYI CRAVICRCTT YDGIDGLPLP SMLQDFLKEY HYKQKVRVRW LEREPIKAK
//
