ID A0A7N4PA46_SARHA Unreviewed; 1281 AA.
AC A0A7N4PA46;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE RecName: Full=CAP-Gly domain-containing protein {ECO:0000259|PROSITE:PS50245};
GN Name=CLIP1 {ECO:0000313|Ensembl:ENSSHAP00000034838.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000034838.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000034838.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000034838.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSSHAT00000028138.1; ENSSHAP00000034838.1; ENSSHAG00000009381.2.
DR GeneTree; ENSGT00940000155122; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:TreeGrafter.
DR GO; GO:0035371; C:microtubule plus-end; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:TreeGrafter.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:TreeGrafter.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IEA:TreeGrafter.
DR FunFam; 2.30.30.190:FF:000002; CAP-Gly domain containing linker protein 1; 1.
DR FunFam; 2.30.30.190:FF:000001; Putative CAP-Gly domain-containing linker protein 1; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 2.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR032108; CLIP1_ZNF.
DR PANTHER; PTHR18916:SF44; CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 1; 1.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR Pfam; PF01302; CAP_GLY; 2.
DR Pfam; PF16641; CLIP1_ZNF; 2.
DR SMART; SM01052; CAP_GLY; 2.
DR SUPFAM; SSF74924; Cap-Gly domain; 2.
DR PROSITE; PS00845; CAP_GLY_1; 2.
DR PROSITE; PS50245; CAP_GLY_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 78..120
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT DOMAIN 234..276
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 351..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 578..1063
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1089..1195
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..170
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1281 AA; 144004 MW; CD61139B8BEE92EE CRC64;
MSMLKPSGLK APTKISKPGS TALKTPTPVP APVEKALSIE KTSSTPSPET HEEFVDDFRV
GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND GSVAGVRYFQ CEPLKGIFTR
PSKLTRKVTS EDEANGTQAP PASRATSPLS TSMTSMAASS SAAPSPSTAP HKVSQPVAKE
SSTTPQISNL TKTASESISN LSEAGSVKKG ERELKINDRV LVGGTKAGVV RFLGETDFAK
GEWCGVELDE PLGKNDGAVA GTRYFQCQPK YGLFAPVHKV TKIGFPSTTP AKAKAAAVRK
VMGTPGSLKR SPSASSLSSL SSVASSVSSK PSRTGLLTET SSRYARKISG TTALQEALKE
KQQHIEQLLA ERDLERAEVA KATSHVGEIE QELALARDGH EQHVLEMEAK MDQLRAMVEA
ADREKVELLN QLEEEKRKVE DLQFRVEEES ITKGDLETQT KLEHARIKEL EQSLLFEKTK
ADKLQRELED TRVATVSEKS RIMELERDLT LRIQEVAELR RSLESNKPAG DVDTSLSLLQ
EISTLQEKLE AMHIDHQHEI ISLKEHFGAT EECHQKEVKA LHAASEKLSK ENESLKSKLD
HANKENSEVI ALWKSKLESA IASHQQAMEE LKVSFSKSVG TETAEFAELK TQIEKLKLDY
QDEIENLKCK QDSERSAHAK EMEILKNKLM KIIKEKEQGL EGLKLQMEKA EDQHLVEMED
ALNKLQEAEI KKKKFADASE ESVAIQQKMQ DMEEKFKEKD EREQQLMETK EKLESEIVEI
MKMSGDNSSQ LTKMNEELRL KDKFVEELQL QLSKANDEAA LLQKSIGEAT LKAEQDQKNI
IAKHEEEKKE LQKKVLDLEK QIEVSHSQCK DLQARHEKAN SETITKHEAV LHSLKKALLD
TEGTLKEAQR KNTDLLKEME ELKKQADKAK VAQTAEDAMQ LMEQMTKEKT ETLASLEDTR
QTNEKLKNEL DALKENNSKN VEELNKSKER LTVENQKMEE FRKEIEALKQ TAAWKSQQLS
ALQEENLKLA EELGRSREEV TSHQKQEGER SVLNNQLLEM KKRESVYKAD TDEERASLQK
SISITSALLT EKDAELEKLR NEVTVLRGEN ASAKSLHSVV QSLESDKVKL ELKVKNLELK
LKENQRQLSG FGGNSEEEER AQESQQMIDF LNSVIVDLQR KNQDLKMKVE MMSEAALNGN
DLNNYDSDDQ EKQFKKKPRL FCDICDCFDL HDTEDCPTQT QVSEDPPHST HHGSRSEERP
YCEICEMFGH WATNCNDDET F
//
